
ALL updates
Quiz by Sadeq K. Ali Al-Salait
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17 questions
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- Q1What is the most common extramedullary site of leukemic infiltration in ALL?Liver, spleen, and lymph nodesPancreasKidneysHeartAdrenal glands30s
- Q2What cytogenetic abnormality defines Philadelphia chromosome-positive ALL?t(12;21)/ETV6::RUNX1t(1;19)/TCF3::PBX1t(v;11q23)/KMT2A rearrangedt(9;22)(q34.1;q11.2)/BCR::ABL1t(5;14)/IL3::IGH30s
- Q3Which classification system includes new subtypes of ALL based on genomic studies?WHO 2016 with updatesICC (International Consensus Classification)FAB classificationTNM classificationRAI staging30s
- Q4Which genetic abnormality is associated with a better prognosis in pediatric ALL?Near haploidyBCR::ABL1 fusionETV6::RUNX1 fusionHypodiploidyMYC rearrangement30s
- Q5Which clinical feature is uncommon but may occur in childhood T-cell ALL?SplenomegalyRecurrent infectionsAnterior mediastinal massTesticular involvementPetechiae30s
- Q6Which mutation activates the JAK-STAT pathway in BCR::ABL1-like ALL?MLL rearrangementFLT3 ITDTP53 deletionCRLF2 rearrangementKRAS mutation30s
- Q7What is the primary role of MRD (minimal residual disease) monitoring in ALL management?Determining initial diagnosisPredicting secondary malignanciesEvaluating response to treatment and relapse riskAssessing extramedullary spreadMonitoring infection risks30s
- Q8What is a characteristic feature of lymphoblasts in ALL on morphology?Abundant basophilic cytoplasmAzurophilic granules
Nuclear outline irregularities
Multi-lobed nucleiScant cytoplasm and condensed chromatin30s - Q9Which test differentiates de novo Ph+ ALL from CML in lymphoid blast phase?Detection of p190 BCR::ABL1 transcriptImmunophenotypingBone marrow biopsyCytogenetics for t(12;21)30s
- Q10What immunophenotypic markers are consistent with B-ALL?CD2, CD3, CD5CD19, cCD79a, CD10CD4, CD8, CD25CD34, TdT, MPO30s
- Q11What cytogenetic abnormality in ALL is associated with hyperdiploidy?Loss of chromosome 7Gain of multiple chromosomest(9;22)/BCR::ABL1Isochromosome 17qt(4;14)/IGH::NSD230s
- Q12What is the function of t(5;14)/IL3::IGH in ALL?Increases interleukin-3 productionActivates the JAK2 pathwayCauses chromatin remodelingSuppresses lymphoid differentiationEnhances myeloid differentiation30s
- Q13Which extramedullary site is most often involved in T-ALL?CNSLiverGonadsKidneysThymus30s
- Q14What is the significance of IKZF1 deletions in ALL?Found exclusively in T-ALLReduces MRD detectabilityAssociated with poor outcomes and relapsePredicts good prognosisUnrelated to relapse risk30s
- Q15What is the recommended first-line therapy for Ph+ ALL in adults?Stem cell transplantMonoclonal antibody therapyConventional chemotherapyRadiation therapyTKI (Tyrosine Kinase Inhibitor) with chemotherapy30s