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ALL updates

Quiz by Sadeq K. Ali Al-Salait

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17 questions
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  • Q1
    What is the most common extramedullary site of leukemic infiltration in ALL?
    Liver, spleen, and lymph nodes
    Pancreas
    Kidneys
    Heart
    Adrenal glands
    30s
  • Q2
    What cytogenetic abnormality defines Philadelphia chromosome-positive ALL?
    t(12;21)/ETV6::RUNX1
    t(1;19)/TCF3::PBX1
    t(v;11q23)/KMT2A rearranged
    t(9;22)(q34.1;q11.2)/BCR::ABL1
    t(5;14)/IL3::IGH
    30s
  • Q3
    Which classification system includes new subtypes of ALL based on genomic studies?
    WHO 2016 with updates
    ICC (International Consensus Classification)
    FAB classification
    TNM classification
    RAI staging
    30s
  • Q4
    Which genetic abnormality is associated with a better prognosis in pediatric ALL?
    Near haploidy
    BCR::ABL1 fusion
    ETV6::RUNX1 fusion
    Hypodiploidy
    MYC rearrangement
    30s
  • Q5
    Which clinical feature is uncommon but may occur in childhood T-cell ALL?
    Splenomegaly
    Recurrent infections
    Anterior mediastinal mass
    Testicular involvement
    Petechiae
    30s
  • Q6
    Which mutation activates the JAK-STAT pathway in BCR::ABL1-like ALL?
    MLL rearrangement
    FLT3 ITD
    TP53 deletion
    CRLF2 rearrangement
    KRAS mutation
    30s
  • Q7
    What is the primary role of MRD (minimal residual disease) monitoring in ALL management?
    Determining initial diagnosis
    Predicting secondary malignancies
    Evaluating response to treatment and relapse risk
    Assessing extramedullary spread
    Monitoring infection risks
    30s
  • Q8
    What is a characteristic feature of lymphoblasts in ALL on morphology?
    Abundant basophilic cytoplasm
    Azurophilic granules

    Nuclear outline irregularities

    Multi-lobed nuclei
    Scant cytoplasm and condensed chromatin
    30s
  • Q9
    Which test differentiates de novo Ph+ ALL from CML in lymphoid blast phase?
    Detection of p190 BCR::ABL1 transcript
    Immunophenotyping
    Bone marrow biopsy
    Cytogenetics for t(12;21)
    30s
  • Q10
    What immunophenotypic markers are consistent with B-ALL?
    CD2, CD3, CD5
    CD19, cCD79a, CD10
    CD4, CD8, CD25
    CD34, TdT, MPO
    30s
  • Q11
    What cytogenetic abnormality in ALL is associated with hyperdiploidy?
    Loss of chromosome 7
    Gain of multiple chromosomes
    t(9;22)/BCR::ABL1
    Isochromosome 17q
    t(4;14)/IGH::NSD2
    30s
  • Q12
    What is the function of t(5;14)/IL3::IGH in ALL?
    Increases interleukin-3 production
    Activates the JAK2 pathway
    Causes chromatin remodeling
    Suppresses lymphoid differentiation
    Enhances myeloid differentiation
    30s
  • Q13
    Which extramedullary site is most often involved in T-ALL?
    CNS
    Liver
    Gonads
    Kidneys
    Thymus
    30s
  • Q14
    What is the significance of IKZF1 deletions in ALL?
    Found exclusively in T-ALL
    Reduces MRD detectability
    Associated with poor outcomes and relapse
    Predicts good prognosis
    Unrelated to relapse risk
    30s
  • Q15
    What is the recommended first-line therapy for Ph+ ALL in adults?
    Stem cell transplant
    Monoclonal antibody therapy
    Conventional chemotherapy
    Radiation therapy
    TKI (Tyrosine Kinase Inhibitor) with chemotherapy
    30s

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