BL
Quiz by Sadeq K. Ali Al-Salait
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- Q1
Which of the following chromosomal translocations is the hallmark of Burkitt lymphoma (BL)?
t(8;14
t(15;17)
t(11;14)
t(9;22)
t(14;18)
30s - Q2
Which oncogene is most strongly implicated in the pathogenesis of BL?
c-MYC
NOTCH1
TP53
JAK2
BCL6
30s - Q3
Which molecular alteration is a key additional driver of Burkitt lymphoma beyond the MYC translocation?
FLT3-ITD mutation
NPM1 mutation
PML-RARA fusion
KRAS mutation
ID3 and TCF3 mutations disrupting B-cell differentiation
30s - Q4
Which histopathological hallmark is characteristic of BL?
Nodular pattern
Intra-sinusoidal infiltration
Perivascular infiltration
Para-trabecular pattern
Diffuse infiltration with "Starry sky" appearance
30s - Q5
Which immunophenotypic markers are typically expressed in BL?
CD19, CD79a, CD19, CD10, cCD22
CD19, CD20, CD10, BCL6, surface IgM
CD19, CD10, CD34, HLA-DR
CD19, TdT, CD10, cCD79A
CD19, CD10, CD38, CD117
30s - Q6
Which BL variant has the highest Epstein-Barr virus (EBV) association?
Immunodeficiency-associated BL
Adult sporadic BL
Sporadic BL
Endemic BL
None, as EBV is not implicated in BL
30s - Q7
Which feature distinguishes BL from diffuse large B-cell lymphoma (DLBCL)?
Frequent BCL2 expression
Presence of centroblasts
high Ki-67 index
Large, irregular nuclei
High mitotic index
30s - Q8
Which condition closely mimics BL but lacks MYC translocation?
Burkitt-like lymphoma with 11q aberration
Lymphoblastic lymphoma
Hodgkin's lymphoma, lymphocyte predominance variant
Diffuse large B-cell lymphoma (DLBCL)
Mantle cell lymphoma
30s - Q9
Which laboratory abnormality is most indicative of high tumor burden in BL?
Decreased albumin
Peripheral blood blast count
Markedly elevated lactate dehydrogenase (LDH)
Hypercalcemia
Increased C-reactive protein
30s - Q10
What is the most common clinical presentation of sporadic BL in adults?
Splenomegaly
Abdominal mass with bowel obstruction symptoms
Cutaneous nodules
Jaw involvement
Mediastinal mass
30s - Q11
A patient with BL is started on high-dose chemotherapy. On day two, he develops acute renal failure, hyperkalemia, hyperphosphatemia, and hypocalcemia. What is the most likely cause?
Septic shock
Tumor lysis syndrome (TLS)
Immune complex nephropathy
Drug-induced nephrotoxicity
Hemophagocytic lymphohistiocytosis
30s - Q12
A 45-year-old male in remission from BL presents 8 months after treatment with recurrent disease. What is the prognosis?
High chance of long-term remission with low-dose chemotherapy
Favorable with re-induction and auto-SCT
High chance of long-term remission with rituximab alone
Favorable prognosis with salvage chemotherapy
Very poor prognosis, as relapsed BL is often refractory to therapy
30s