Bleeding disorders

Gastrointestinal bleeding is commonly the initial presenting symptom in patients with von Willebrand disease

Bleeding symptoms associated with von Willebrand disease typically worsen with the use of oral contraceptives

More men than women are affected by von Willebrand disease, and the phenotype is more pronounced in men

Bleeding associated with von Willebrand disease may occur as long as several weeks after surgery

Coagulation correction should be delayed until diagnostic testing is completed in patients with suspected hemophilia B

Ultrasonography is useful in evaluating bone and cartilage affected by hemophilia B

A normal prolonged activated partial thromboplastin time (aPTT) test result excludes hemophilia B

Spontaneous bleeding complications are severe in individuals with hemophilia B who have undetectable activity on factor IX assay

Petechiae are among the most common presenting symptoms in patients with hemophilia A

Unlike other bleeding conditions, hemophilia A is primarily seen in women

A traumatic challenge relatively late in life may have to occur before mild or moderate hemophilia A is diagnosed

The muscles most commonly affected in patients with hemophilia A are the pectoral muscles and the abdomen

For patients with mild to moderate von Willebrand disease, antifibrinolytic agents combined with desmopressin are generally effective for oral surgery

Subcutaneous administration of desmopressin is recommended above intravenous or intranasal administration in patients with von Willebrand disease

Patients with von Willebrand disease should be advised to use nonsteroidal anti-inflammatory drugs (NSAIDs) as opposed to aspirin

All patients with severe von Willebrand disease should receive regular prophylactic infusions of von Willebrand factor to prevent bleeding episodes

Regular standardized evaluation at least every 12 months is recommended in patients with hemophilia

Treatment with intravenous injection of factor concentrate is able to reverse established joint damage in patients with mild to moderate hemophilia

Implanted venous access devices are contraindicated in younger children with hemophilia

Prophylactic oral antibiotics should be routinely prescribed in all patients with hemophilia prior to undergoing any dental procedure