Carrier mediated transport
Quiz by Anil Philip
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- Q1
What is the primary mechanism by which levodopa crosses the blood-brain barrier?
Active transport via P-glycoprotein
Passive diffusion
Endocytosis
Carrier-mediated transport via LAT1
30s - Q2
Which factor can inhibit the transport of levodopa across the BBB?
Enhanced BBB permeability
Increased LAT1 expression
Competitive inhibition by other amino acids
Low dietary protein intake
30s - Q3
What role does LAT1 play in levodopa transport?
It converts levodopa to dopamine in the bloodstream
It facilitates the selective transport of levodopa
It degrades levodopa before it reaches the brain
It acts as a barrier to prevent drug entry
30s - Q4
How can dietary protein intake affect levodopa therapy?
High protein intake enhances levodopa absorption
High protein intake competes with levodopa for LAT1 transport
Protein intake has no effect on levodopa therapy
Low protein intake reduces levodopa efficacy
30s - Q5
A 70-year-old patient with Parkinson's disease is experiencing reduced efficacy of levodopa therapy. The patient reports a high-protein diet. What is the most likely reason for the reduced efficacy?
Enhanced clearance of levodopa by the kidneys
Decreased production of dopamine in the brain
Increased levodopa metabolism in the liver
Competitive inhibition of levodopa transport by dietary amino acids
30s