Celiac disease
Quiz by Nada Hassan Ahmed Abdelrahman
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- Q1What is the genetic relation to Celiac Disease?HLA-DQ 3 and HLA- DQ 8 alleles.HLA-DQ 4 and HLA- DQ 8 alleles.HLA-DQ 4 and HLA- DQ7 alleles.HLA-DQ 2 and HLA- DQ 8 alleles.30s
- Q2What part of the alimentary canal is affected by celiac disease?ColonSmall bowel mainly Duodenumoesophagusterminal ileum30s
- Q3What is the histopathological feature of Celiac?Villous hyperplasiaCrypt atrophyVillous atrophy30s
- Q4What is the gold standard for the diagnosis of celiac disease?Serum calciumIgA tissue transglutaminase antibodiesTissue biopsyAnti-gliadin antibody30s
- Q5What is the skin lesion associated with celiac diseaseDermatitis herpetiformisEczemaPemphigoidBullous Pemphguis30s
- Q6
A 1 3-year-old girl presents with frequently foul-smelling diarrhoea, particularly after eating pasta or bread. Physical examination shows excoriated papules and vesicles on her elbows, knees, back, and buttocks. She is in the 10th percentile on the growth curve for height and weight. An endoscopic small bowel biopsy is obtained and is shown below. Which of the following gastrointestinal neoplasm is she at the greatest risk of developing if her disease becomes refractory to treatment?
Adenocarcinoma
Carcinoid
Gastrointestinal stromal tumour
T-cell lymphoma
60s - Q7
A 22-year-old man presents with foul-smelling and bulky stools for the past 6 months. The patient also lost 4.5-kg (10-lb) over this time period as well. A D-xylose test and small bowel series are ordered, and the results are normal. Which of the following is the most likely diagnosis?
Small intestinal bacterial overgrowth
Celiac disease.
Crohn disease
Pancreatic insufficiency
45s - Q8
A 32-year-old Caucasian woman presents with an "itchy rash." She has had it off and on for years, but it has been particularly bad in the last 6 months. She explains the rash usually occurs on her forearms and elbows, but she has also had it on her back and buttocks. She tries to not scratch, but "can't help sometimes because it's so itchy." She has tried lotions and moisturizers with no improvement. She had a thyroidectomy in her twenties due to Graves' disease and currently takes levothyroxine. She endorses occasional headaches, anxiety about her job, as well as frequent nausea and loose stools after meals. Examination shows multiple, grouped vesicles and papules distributed over her dorsal forearms, elbows, back and buttocks. Multiple excoriations are noted. Which of the following tests will likely confirm the diagnosis?
Patch testing with multiple fabric types
Un-roof vesicle and send for viral analysis
anti-gliadin antibodies IgA and IgM testing
Antinuclear antibody testing
60s - Q9
A 15-year-old boy presents with an intensely itchy rash on his elbows and knees. He states that the rash began as small vesicles a week ago. Family history is significant for Graves disease in his mother. Physical examination shows excoriated papules and erosions that are crusted over on his elbows, knees, and buttocks, as shown below. Which of the following is most likely to confirm the diagnosis?
Skin biopsy
Mite detection with skin scraping with microscopy
Anti-nuclear antibody testing
Potassium hydroxide preparation of skin scraping with microscopy
45s - Q10
A 37-year-old presents with multiple episodes of diarrhoea and bloating for several years. She thinks she has lost weight because of this indigestion. She also has some itchy vesicles on her arms and legs. Physical examination shows abdominal distention as well as mucosal and conjunctival pallor. Antibodies against which of the following are more likely associated with her condition?
Perimysium
Epimysium
Desmoglein
Endomysium
60s - Q11
A 40-year-old man comes to the office because of diarrhoea and abdominal cramps. He says that he was diagnosed with celiac disease 15 years ago, but is beginning to eat gluten-containing food again because he thought that he would be able to tolerate it now. Which of the following cellular patterns would most likely be found on a biopsy of this patient's small intestine?
Non-necrotizing crypt granulomas
Intraepithelial lymphocytes
Neutrophilic infiltration of lumen and tissue
Crypt abscesses with inflammatory neutrophils
45s - Q12
A 15-year-old girl presents with abdominal pain, diarrhoea, flatulence, and borborygmi. The only known relieving factor is not eating, and as a consequence, she has lost 6.8-kg (15-lb) in 6 weeks. She is earning excellent grades in school and is involved in numerous extracurricular activities. She denies any new stress or unusual behaviour. She has noticed numerous fluid-filled blisters along her arms and legs, as shown below. Her temperature is 37.6°C (99.7°F), her pulse is 88/min, her respirations 13/min, and her blood pressure 118/80 mm Hg. Serologic evaluation is positive for anti-tissue transglutaminase IgA and anti-endomysial IgA. Which of the following is most likely seen on abdominal radiograph with barium contrast?
Decreased jejunal folds, increased ileal folds
Decreased jejunal folds, decreased ileal folds
Increased jejunal folds, decreased ileal folds
Increased jejunal folds, increased ileal folds
120s - Q13
A 1 3-year-old girl presents with frequently foul-smelling diarrhoea, particularly after eating pasta or bread. Physical examination shows excoriated papules and vesicles on her elbows, knees, back, and buttocks. She is in the 10th percentile on the growth curve for height and weight. An endoscopic small bowel biopsy is obtained and is shown below. Which of the following gastrointestinal neoplasm is she at the greatest risk of developing if her disease becomes refractory to treatment?
T-cell lymphoma
Gastrointestinal stromal tumour
Adenocarcinoma
Carcinoid
60s - Q14
A 22-year-old man presents with foul-smelling and bulky stools for the past 6 months. The patient also lost 4.5-kg (10-lb) over this time period as well. A D-xylose test and small bowel series are ordered, and the results are normal. Which of the following is the most likely diagnosis?
Pancreatic insufficiency
Crohn disease
Small intestinal bacterial overgrowth
Celiac disease.
45s - Q15
A 32-year-old Caucasian woman presents with an "itchy rash." She has had it off and on for years, but it has been particularly bad in the last 6 months. She explains the rash usually occurs on her forearms and elbows, but she has also had it on her back and buttocks. She tries to not scratch, but "can't help sometimes because it's so itchy." She has tried lotions and moisturizers with no improvement. She had a thyroidectomy in her twenties due to Graves' disease and currently takes levothyroxine. She endorses occasional headaches, anxiety about her job, as well as frequent nausea and loose stools after meals. Examination shows multiple, grouped vesicles and papules distributed over her dorsal forearms, elbows, back and buttocks. Multiple excoriations are noted. Which of the following tests will likely confirm the diagnosis?
anti-gliadin antibodies IgA and IgM testing
Antinuclear antibody testing
Un-roof vesicle and send for viral analysis
Patch testing with multiple fabric types
120s
