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Drug-Induced Kidney Disease

Quiz by Heather Powell

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38 questions
Show answers
  • Q1
    True or False. Cumulative dose-dependent nephrotoxicity will occur unpredictably.
    False
    True
    30s
  • Q2
    True or False. Idiosyncratic dose-independent nephrotoxicities are unpredictable.
    False
    True
    30s
  • Q3
    NSAIDs cause DIKD via which of the following mechanisms?
    Efferent arteriole vasodilation
    Afferent arteriole vasodilation
    Afferent arteriole vasoconstriction
    Efferent arteriole vasoconstriction
    30s
  • Q4
    ACE-Is cause DIKD via which of the following mechanisms?
    Efferent arteriole vasodilation
    Afferent arteriole vasoconstriction
    Afferent arteriole vasodilation
    Efferent arteriole vasoconstriction
    30s
  • Q5
    Which of the following would be indicative of ACE-I induced DIKD?
    Irreversible upon drug discontinuation
    Rise in SCr > 30% from baseline within 3-5 days
    BUN/SCr ratio of 15:1
    Stabilization of SCr within 1 week of drug start
    30s
  • Q6
    Which of the following is a unique risk factor for development of ARB induced DIKD?
    Steroid administration
    Bilateral renal artery stenosis
    Exposure to hypertonic fluids
    Increased age
    30s
  • Q7
    NSAID-induced DIKD will present with urine indices of what sort?
    Intrinsic
    Post-renal
    Pre-renal
    30s
  • Q8
    Which of the following is NOT associated with the development of ATN?
    Aminoglycosides
    Lithium
    Contrast media
    Amphotericin B
    30s
  • Q9
    Which of the following disease state combinations puts patients at the highest risk of developing ATN from contrast media?
    CHF and CKD
    Afib and BPH
    DM and CKD
    DM and Afib
    30s
  • Q10
    True or false: Amphotericin B desoxycholate has a HIGHER propensity to cause ATN compared to Amphotericin B lipid-based formulation.
    False
    True
    30s
  • Q11
    Which of the following is an approximate timeline of SCr increase if a patient has developed aminoglycoside-induced DIKD (i.e. time after drug initiation)?
    5-10 days
    14 days
    < 24 hours
    48 hours
    30s
  • Q12
    True or False: The anionic charge of gentamicin leads to tubular epithelial cell binding and uptake of the drug.
    False
    True
    30s
  • Q13
    Which segment of the lumen is typically the most affected by tobramycin DIKD?
    Convoluted Tubule
    Distal Tubule
    Loop of Henle
    Proximal tubule
    30s
  • Q14
    Which of the following is a urine output typically associated with aminoglycoside DIKD?
    750 mL/day
    25 mL/day
    250 mL/day
    100 mL/day
    30s
  • Q15
    Which of the following electrolyte combinations are typically wasted in aminoglycoside-induced DIKD?
    K & Mg
    K & Na
    Na & Ca
    Ca & Phos
    30s

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