
Drug-Induced Kidney Disease
Quiz by Heather Powell
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38 questions
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- Q1True or False. Cumulative dose-dependent nephrotoxicity will occur unpredictably.FalseTrue30s
- Q2True or False. Idiosyncratic dose-independent nephrotoxicities are unpredictable.FalseTrue30s
- Q3NSAIDs cause DIKD via which of the following mechanisms?Efferent arteriole vasodilationAfferent arteriole vasodilationAfferent arteriole vasoconstrictionEfferent arteriole vasoconstriction30s
- Q4ACE-Is cause DIKD via which of the following mechanisms?Efferent arteriole vasodilationAfferent arteriole vasoconstrictionAfferent arteriole vasodilationEfferent arteriole vasoconstriction30s
- Q5Which of the following would be indicative of ACE-I induced DIKD?Irreversible upon drug discontinuationRise in SCr > 30% from baseline within 3-5 daysBUN/SCr ratio of 15:1Stabilization of SCr within 1 week of drug start30s
- Q6Which of the following is a unique risk factor for development of ARB induced DIKD?Steroid administrationBilateral renal artery stenosisExposure to hypertonic fluidsIncreased age30s
- Q7NSAID-induced DIKD will present with urine indices of what sort?IntrinsicPost-renalPre-renal30s
- Q8Which of the following is NOT associated with the development of ATN?AminoglycosidesLithiumContrast mediaAmphotericin B30s
- Q9Which of the following disease state combinations puts patients at the highest risk of developing ATN from contrast media?CHF and CKDAfib and BPHDM and CKDDM and Afib30s
- Q10True or false: Amphotericin B desoxycholate has a HIGHER propensity to cause ATN compared to Amphotericin B lipid-based formulation.FalseTrue30s
- Q11Which of the following is an approximate timeline of SCr increase if a patient has developed aminoglycoside-induced DIKD (i.e. time after drug initiation)?5-10 days14 days< 24 hours48 hours30s
- Q12True or False: The anionic charge of gentamicin leads to tubular epithelial cell binding and uptake of the drug.FalseTrue30s
- Q13Which segment of the lumen is typically the most affected by tobramycin DIKD?Convoluted TubuleDistal TubuleLoop of HenleProximal tubule30s
- Q14Which of the following is a urine output typically associated with aminoglycoside DIKD?750 mL/day25 mL/day250 mL/day100 mL/day30s
- Q15Which of the following electrolyte combinations are typically wasted in aminoglycoside-induced DIKD?K & MgK & NaNa & CaCa & Phos30s