1. During the colonial period, Native Americans (face) many difficulties when interacting with European settlers.

2.  One major issue (be) diseases brought by Europeans that Native Americans had never encountered before, such as smallpox.

3. These diseases (spread) quickly among Native populations, causing widespread illness and death.

4. Another challenge (be) the slave trade, which exploited Native Americans who (be) on the losing side of conflicts between European powers.

5. Many Native individuals (be) enslaved or indentured as a result of these wars, and some (be) even sold and shipped to other colonies or countries as slaves.

6.  These internal divisions (weaken) their ability to resist European encroachment on their lands.

7. This period (mark) just one chapter in the ongoing mistreatment and marginalization experienced by Native Americans in the United States.