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GRN (P2)

Quiz by Yee Ying

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15 questions
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  • Q1
    In a graph model of a Gene Regulatory Network (GRN), what do the nodes and edges typically represent?
    Nodes represent DNA sequences, and edges represent mutational relationships.
    Nodes represent cellular functions, and edges represent physical cell-cell interactions.
    Nodes represent proteins, and edges represent metabolic pathways.
    Nodes represent genes or gene products (such as proteins), and edges represent regulatory interactions.
  • Q2
    Which type of network analysis is more informative?
    Retrospective Lineage Tracing
    Prospective Lineage Tracing
    Dynamical Modelling
    Static Network Analysis
  • Q3
    How can scientists build biological networks?
    Using databases
    By making predictions
    Through experiments
    All of the above
  • Q4
    In GRN, what does a directed graph indicate?
    Edges do not have an exact direction.
    There is no interaction between nodes.
    Edges are oriented, indicating modulation.
    Only physical interactions are considered.
  • Q5
    What are nodes in a biological network often representative of?
    Only transcription factors
    Only proteins
    Genes, mRNAs, TFs, etc.
    Only genes
  • Q6
    What is a key difference between static and dynamic network analysis in studying gene regulatory networks?
    Static network analysis identifies cell types, while dynamic does not.
    Static network analysis focuses on gene expression equilibrium, whereas dynamic does not.
    Only static network analysis can determine cluster-based gene expression similarity.
    Dynamic network analysis captures the temporal evolution of the transcriptome, unlike static analysis.
  • Q7
    Static network analysis does not provide information on:
    Cluster-based gene expression similarity
    Gene expression equilibrium
    Cell type identification
    Temporal evolution of the transcriptome
  • Q8
    Dynamical modelling in GRN inference is based on:
    Gene expression measured at several time points
    Gene expression measured at one time point
    Static state gene expression analysis
    Only the final state of gene expression
  • Q9
    Which type of experiment involves perturbing cells and observing changes over time?
    Static network analysis
    Retrospective lineage tracing
    Dynamical modelling
    Prospective lineage tracing
  • Q10
    Single cell RNA-seq is increasingly used for:
    Lineage trajectories and determining cell fate
    Only cell classification
    Only determining cell fate
    Only trajectory analysis
  • Q11
    Which mathematical representations are utilized in biological network analysis?
    Neural networks only
    Linear equations only
    Directed and undirected graphs
    Physical maps only
  • Q12

    What is true about the edges (or links) in biological networks? (Choose all thatapply)

    I. Represent physical interactions betweenmolecular components

    II. Can indicate both activation andinhibition

    III. Are always unidirectional

    IV. Encode conditional dependencies betweengenes

    I & II

    III & IV

    I, III & IV

    All of the above

  • Q13

    Which approach is used for retrospective lineage tracing? (Choose all that apply)

    I. Prospective lineage tracing

    II. Static network analysis

    III. Dynamical modelling

    IV. Physical interaction mapping

    All of the above

    III only

    I & IV

    II &III

  • Q14

    Which of the following methods is used to obtain biological networks? (Choose all that apply)

    I. A collection of databases

    II. High-throughput experiments

    III. Manual observations

    IV. Large-scale bioinformatics predictions


    I & II


    I, II & IV

  • Q15

    Which of the following are true about Gene Regulatory Networks (GRN)? (Choose all that apply)

    I. Involve the regulation of one gene by another.

    II. Include protein-to-gene feedback loops.

    III. Solely based on physical interactionbetween genes.

    IV. Can be simple or highly complexdepending on the number of genes involved.

    I, II & IV



    I & II


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