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Heart's Energy Requirements and Sources

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11 questions
Show answers
  • Q1
    There is a _________ relationship between the rate of mitochondrial respiration, blood flow, and workload.
    Parabolic
    Logarithmic
    Exponential
    Linear
    120s
  • Q2
    What is the resting heart's main source of fuel?
    Fatty acids
    Lactate
    Glucose
    Ketone bodies
    120s
  • Q3
    The heart muscle functions almost exclusively aerobically
    False
    True
    120s
  • Q4
    ATP is primarily used by the heart for ionic homeostasis.
    False
    True
    120s
  • Q5
    Which of these is not a major, high energy phosphate in the heart?
    Creatine phosphate (PCr)
    Adenosine triphosphate
    Adenosine diphosphate
    120s
  • Q6
    Oxidative phosphorylation accounts for more than 95% of the ATP synthesised in the heart.
    False
    True
    120s
  • Q7
    Which pathway of fatty acid beta oxidation in the heart is correct?
    Uptake of free fatty acids from plasma with fatty acid transport proteins --> activated by acetyl-CoA synthetase --> esterified with coenzyme A to form soluble fatty acetyl-CoA --> permeation into mitochondria of cardiac myocytes --> fatty acid beta-oxidation takes place in the mitochondrial matrix --> produces acetyl-CoA that enters the Krebs cycle as well as NADH and FADH2 that enters the electron transport chain
    Uptake of free fatty acids from plasma with fatty acid transport proteins --> permeation into mitochondria of cardiac myocytes --> activated by acetyl-CoA synthetase --> esterified with coenzyme A to form soluble fatty acetyl-CoA --> fatty acid beta-oxidation takes place in the mitochondrial matrix --> produces acetyl-CoA that enters the Krebs cycle as well as NADH and FADH2 that enters the electron transport chain
    Uptake of free fatty acids from plasma with fatty acid transport proteins --> permeation into mitochondria of cardiac myocytes --> fatty acid beta-oxidation takes place in the mitochondrial matrix --> activated by acetyl-CoA synthetase --> esterified with coenzyme A to form soluble fatty acetyl-CoA --> produces acetyl-CoA that enters the Krebs cycle as well as NADH and FADH2 that enters the electron transport chain
    120s
  • Q8
    Myocardial glucose transport does not depend on:
    Insulin
    Blood glucose concentration
    Transport proteins
    Quantity of ketone bodies produced by the liver
    120s
  • Q9
    The contribution of glycolysis is relatively decreased under ischaemic or anaerobic conditions.
    False
    True
    120s
  • Q10
    What is the purpose of regulation of the pyruvate dehydrogenase reaction by fatty acids?
    To regulate myocardial substrate choice and utilisation
    To regulate the rate of the pyruvate dehydrogenase reaction
    To regulate the process of glycolysis
    120s
  • Q11
    In the heart, ketone bodies are transformed into acetyl-CoA, which enters the citric acid cycle.
    False
    True
    120s

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