the relative count in % multipled by wbc count

wbc greater than 10,000/ul adult

wbc less than 4,000 /ul adult

associated with stress, fever, labor strenuous exercise tachycardia

transient redistribution of marginal neutrophil pool associted with acute stress , lasts 20-30 minutes

circulating, marginal, bone marrow

more immature neutrophils are present

wbc count usually less than 50,000/ul, shift to left elevated LAP

order of wbc's from most common to least in adult

extreme neutrophlic response, with various stages with elevated LAP

autoantibodies to wbc

circulating neutrophils binding to marginal epithelial

purple granules in cytoplasm of wbcs, cell function normally

defect in respiratory burst killing mechanisms, cell ingest but don't kill

EBV

heterophile antibody

process that stops blood flow

oxygen carrying protein

blood vessels,platelets,coag factors,fibrinolysis

erythrocyte (rbc)

vessel contracts

protects the body from infectious microorganisms. 2 types are Granulocyte and Agranulocytes

adhere, aggregate, activate

consist of neutrophils , eosinophils and basophils

inhibits thrombin

destroys bacteria and most numerous WBC

inactivates factors Va & VIII a

play a role in allergic reactions

prevent activation of prothrombin by Xa

function in inflammation medication and similar in function to mast cells

inhibits factor Xa

consist of lymphocytes and monocytes

released from injured vessel

the most important cell of the immune system, effective in fighting infectious organisms; act against a specific foreign molecule (antigen)

activates platelets

transform into macrophages; phagocytic cells

after collagen interaction shape change and activation

structure: originate in bone marrow and contain several clotting factors such as calcium ions, ADPand serotonin.

factors II,VII, IX, X

the stop of bleeding when a blood vessel is damaged/ dead

process by which blood cells are formed

needs PF3, factor Va, and calcium ions

requires thrombin

transport oxygen and carbon dioxide

fibrinogen

Prothrombin

thromboplastin, tissue factor TF

ionized calcium CA++

prothrombin accelerator

Proconvertin, Stable Factor

antihemophilic factor

Christmas factor, plasma thromboplastin component (PTC)

give rise to lymphocytes

Stuart-Prower factor

give rise to all other blood cells

Plasma thromboplastin antecedent (PTA)

recycles damaged or dead RBCs

Hageman factor (contact factor)

measure of % RBC

the most common test that is done. it test the hemoglobin level, hematocrit, RBC count, WBC and platelet count

Fibrin stabilizing factor

high molecular weight kininogen

most common normal adult hemoglobin

Prekallikrein

Hemoglobin A1 structure

PF3, V and CA++ initiate this change

hemoglobin f structure

thrombin converts this

Hemoglobin A2 structure

inactive form of plasmin

Same as packed cell volume

normal hct

fibrinogen,FDP's,XDP's

factor III (thromboplastin) not present in circulating blood

3Xrbc=hgbX3 = HCT

all factors are in circulations

200X higher affinity than Oxygen for hgb

activated by intrinsic and extrinsic pathways

recycles rbcs

factor VIIIa and VIIa convert this

120 days

warfarin (coumadin), Heparin,Plavix,Aspirin

8-10 days

inhiibits Vitamin K factors (II,VII,IX,X)

varies hours to years

acronym for most to least common wbc

inhibits thrombin and factor X

inhibits platelet aggregation

measures nine parameters

inhibits platelet aggregation and release of PF3

normal plt numbers

hemophilia is example

normal wbc numbers

examples Vit K deficiency or aspirin on platelets

normal rbc numbers

factor VIII deficiency

under 20,000 platelets

Chistmas disease or factor IX deficiency

embolus

associated with a small infectious particle, non DNA or RNA just self replicating protein

thrombis

recombinant, gene therapy

normal platelet count, decreased adhesion

large platelet decreased plt count, poor adherence

normal plt count , morphology adhesion unable to aggregate

intratravascular clotting

antibodies directed against platelets

inactivates platelets for their lifespan

aggregation studies for plt function

vascular integrity and platelet functino

tests extrinsic pathway

tests intrinsic pathway