IDA
Quiz by Sadeq K. Ali Al-Salait
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- Q1
A 68-year-old man presents with fatigue. Labs show Hb 9 g/dL, MCV 70 fL, low ferritin, and low serum iron. What is the next step in management?
Check folate level to exclude nutritional deficiency
Start oral iron therapy
Bone marrow examination to exclude MDS
Blood transfusion
Colonoscopy to rule out malignancy
30s - Q2
A 35-year-old woman with heavy menstrual bleeding presents with fatigue and pallor. CBC shows microcytic anemia with low serum ferritin. What is the next best step?
Send for Coeliac screen
Transfuse packed RBCs immediately
Perform upper GI endoscopy
Start oral iron therapy and investigate the cause of bleeding
Perform bone marrow biopsy
30s - Q3
A 28-year-old pregnant woman in her second trimester presents with fatigue. Labs show Hb 10 g/dL, low ferritin, and low transferrin saturation. What is the best treatment?
Oral iron supplementation
IV iron
Blood transfusion
Erythropoietin
Folic acid alone
30s - Q4
A 55-year-old male with CKD on hemodialysis presents with Hb 8.5 g/dL. His serum ferritin is low. What is the next step?
Bone marrow examination
Blood transfusion
IV iron therapy
Erythropoietin
Oral iron therapy
30s - Q5
A 3-year-old child presents with pallor and poor appetite with history of fever for the last week. Labs show microcytic anemia and borderline ferritin level. We have to consider...?
Dietary iron deficiency
Thalassemia trait with infection
Fanconi anemia
Anemia of chronic disease
Lead poisoning
30s - Q6
Which protein is primarily responsible for iron export from enterocytes into circulation?
Ferroportin
Apoferritin
DMT1
Transferrin
Hepcidin
30s - Q7
In patients with inflammatory diseases, why does iron-deficient erythropoiesis persist despite adequate iron stores?
Decreased intestinal iron absorption
Impaired folate metabolism
Erythropoietin resistance
Hepcidin-mediated sequestration of iron in macrophages
Mitochondrial dysfunction causing misutilization of cellular iron
30s - Q8
Which inherited disorder leads to iron-refractory iron deficiency anemia (IRIDA)?
Diamond-Blackfan anemia
HFE gene mutation
Wilson disease
TMPRSS6 gene mutation
Ferroportin dysfunction
30s - Q9
Which of the following differentiates IDA from anemia of chronic disease (ACD) when both conditions coexist?
Low serum iron
Normal transferrin saturation
High ferritin level
High hepcidin level
Elevated sTfR
30s - Q10
Which IV iron formulation has the lowest risk of anaphylaxis?
Iron dextran
Ferric carboxymaltose
Sodium ferric gluconate
Ferumoxytol
Iron sucrose
30s - Q11
What is the most common side effect of high-dose IV iron therapy?
Neutropenia
Methemoglobinemia
Pancytopenia
Anaphylaxis
Transient hypophosphatemia
30s - Q12
Which of the following best describes the role of erythroferrone (ERFE) in IDA recovery?
Directly stimulate erythropoiesis
Directly stimulates duodenal iron absorption
Enhances transferrin binding to iron
Suppresses hepcidin to enhance iron mobilization
Reduces iron overload
30s