Question 1

What is the primary function of VDJ recombination in the immune system?

Accepted Answer

To generate a diverse repertoire of antibodies

Answer

To activate T cells

Answer

To produce cytokines

Answer

To destroy pathogens directly

Question 2

Which of the following components are involved in the VDJ recombination process?

Accepted Answer

RAG proteins

Answer

MHC molecules

Answer

Cytokines

Answer

Complement proteins

Question 3

In VDJ recombination, what does 'VDJ' stand for?

Accepted Answer

Variable, Diversity, and Joining

Answer

Vaccine, Disease, and Junction

Answer

Viral, Diversity, and Joining

Answer

Variable, Deletion, and Junction

Question 4

What is the role of terminal deoxynucleotidyl transferase (TdT) in VDJ recombination?

Accepted Answer

To add non-templated nucleotides during the joining process

Answer

To facilitate RAG protein activity

Answer

To cleave DNA segments

Answer

To pair homologous chromosomes

Question 5

Which immune cells primarily undergo VDJ recombination to produce antibodies?

Accepted Answer

B cells

Answer

T cells

Answer

Natural killer cells

Answer

Macrophages

Question 6

What initiates the VDJ recombination process in developing B cells?

Accepted Answer

RAG1 and RAG2 proteins

Answer

CD4 molecules

Answer

Antigen receptors

Answer

Interleukins

Question 7

During VDJ recombination, what is the significance of the 'junctional diversity' that occurs?

Accepted Answer

It increases the variability of antibody specificity

Answer

It standardizes antibody production

Answer

It prevents autoimmune responses

Answer

It reduces the number of functional antibodies

Question 8

Which process ensures that only one functional heavy chain and one functional light chain are expressed in a B cell after VDJ recombination?

Accepted Answer

Allelic exclusion

Answer

Isotype switching

Answer

Gene rearrangement

Answer

Clonal selection

Question 9

What occurs if there is an error during the VDJ recombination process?

Accepted Answer

It can lead to the development of autoimmune diseases or lymphomas

Answer

It has no effect on the immune response

Answer

It only affects the B cell's lifespan

Answer

It enhances antibody diversity

Question 10

What role does the recombination signal sequence (RSS) play in VDJ recombination?

Accepted Answer

It directs the RAG proteins to the appropriate sites on the DNA

Answer

It encodes the antibody structure

Answer

It inhibits the recombination process

Answer

It stabilizes the antibody-antigen complex

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