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Introduction in Cancer Biology

Quiz by Mikey Huijben

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14 questions
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  • Q1
    Which two common traits in cancers are the most important in cancer research, leading to the most deaths under cancer patients?
    Metastasis and tissue invasion
    Tissue invasion and insensitivity to antigrowth signals
    Sustained angiogenesis and metastasis
    Sustained angiogenesis and tissue invasion
    120s
  • Q2
    True or false? The heterogeneity of mutations in tumours make it possible to very precisely and quickly cure cancer patients.
    false
    true
    True or False
    45s
  • Q3
    Fill in the correct term, fitting the description. A gain-of-function mutation in these genes can drive a cell toward cancer, since they promote cell growth.
    Users enter free text
    Type an Answer
    45s
  • Q4
    Fill in the correct term, fitting the description. A loss-of-function mutation in this type of gene can contribute to cancer, since they initiate apoptosis when a cell has been damaged.
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    45s
  • Q5
    The pathway of which tumour-suppressor gene is mutated in nearly all human cancers?
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    45s
  • Q6
    The Wikipedia page of the RAS gene states that when Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. Under which class of genes does the RAS gene belong?
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    45s
  • Q7
    Which of the following statements is incorrect?
    An oncogene is a proto-oncogene that is overactive
    An oncogene is a proto-oncogene that is overexpressed
    An oncogene is a proto-oncogene that is mutated
    All statements are correct.
    45s
  • Q8
    Fill in the correct term, fitting the description. The formation of additional blood vessels as a result of a lack of nutrients in malignant cells.
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    45s
  • Q9
    Fill in the correct term, fitting the description. These adhesive transmembrane alpha-beta heterodimers anchor the actin cytoskeleton of cells to the extracellular matrix, transmit mechanical force and signals through the membrane, and control cell migration machinery.
    Freetext://Integrins
    Video
    45s
  • Q10
    Fill in the correct term, fitting the description. The movement of cancer cells away from the point of origin. Also called epithelial-mesenchymal-transition (EMT).
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    Type an Answer
    45s
  • Q11
    Put the following events during EMT in the correct chronological order.
    ordering://Attachment of cells to epithelium by E-cadherin.|1:Recruitment of stromal cells using CSF|2:Release of EGF and TNF-alpha and cathepsin-B by macrophages|3:Cleavage and stop of production of E-cadherin|4:Production of wide flat lamellopodia in the direction of HGF|5:Cancer cells interact with endothelial cells via N-cadherin.|6:Intravasation|7
    Video
    120s
  • Q12
    The subfamily of growth factors called the TGF-beta subfamily belongs to which earlier stated class of genes?
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    45s
  • Q13
    Fill in the correct term, fitting the description. The ability of a cancerous cell to self-renew and differentiate.
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    Type an Answer
    45s
  • Q14
    Put the following events during the TGF-beta growth factor pathway in the correct chronological order.
    Users link answers
    Linking
    120s

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