Introduction in Cancer Biology
Quiz by Mikey Huijben
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14 questions
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- Q1Which two common traits in cancers are the most important in cancer research, leading to the most deaths under cancer patients?Metastasis and tissue invasionTissue invasion and insensitivity to antigrowth signalsSustained angiogenesis and metastasisSustained angiogenesis and tissue invasion120s
- Q2True or false? The heterogeneity of mutations in tumours make it possible to very precisely and quickly cure cancer patients.falsetrueTrue or False45s
- Q3Fill in the correct term, fitting the description. A gain-of-function mutation in these genes can drive a cell toward cancer, since they promote cell growth.Users enter free textType an Answer45s
- Q4Fill in the correct term, fitting the description. A loss-of-function mutation in this type of gene can contribute to cancer, since they initiate apoptosis when a cell has been damaged.Users enter free textType an Answer45s
- Q5The pathway of which tumour-suppressor gene is mutated in nearly all human cancers?Users enter free textType an Answer45s
- Q6The Wikipedia page of the RAS gene states that when Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. Under which class of genes does the RAS gene belong?Users enter free textType an Answer45s
- Q7Which of the following statements is incorrect?An oncogene is a proto-oncogene that is overactiveAn oncogene is a proto-oncogene that is overexpressedAn oncogene is a proto-oncogene that is mutatedAll statements are correct.45s
- Q8Fill in the correct term, fitting the description. The formation of additional blood vessels as a result of a lack of nutrients in malignant cells.Users enter free textType an Answer45s
- Q9Fill in the correct term, fitting the description. These adhesive transmembrane alpha-beta heterodimers anchor the actin cytoskeleton of cells to the extracellular matrix, transmit mechanical force and signals through the membrane, and control cell migration machinery.Freetext://IntegrinsVideo45s
- Q10Fill in the correct term, fitting the description. The movement of cancer cells away from the point of origin. Also called epithelial-mesenchymal-transition (EMT).Users enter free textType an Answer45s
- Q11Put the following events during EMT in the correct chronological order.ordering://Attachment of cells to epithelium by E-cadherin.|1:Recruitment of stromal cells using CSF|2:Release of EGF and TNF-alpha and cathepsin-B by macrophages|3:Cleavage and stop of production of E-cadherin|4:Production of wide flat lamellopodia in the direction of HGF|5:Cancer cells interact with endothelial cells via N-cadherin.|6:Intravasation|7Video120s
- Q12The subfamily of growth factors called the TGF-beta subfamily belongs to which earlier stated class of genes?Users enter free textType an Answer45s
- Q13Fill in the correct term, fitting the description. The ability of a cancerous cell to self-renew and differentiate.Users enter free textType an Answer45s
- Q14Put the following events during the TGF-beta growth factor pathway in the correct chronological order.Users link answersLinking120s