Iridia2
Quiz by Mays Ahmed
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30 questions
Show answers
- Q1What is the primary role of iron in biological reactions?Energy storageOxygen transportCell divisionProtein synthesis30s
- Q2Which protein is the major hormonal regulator of iron homeostasis?FerroportinHepcidinMatriptase-2Transferrin30s
- Q3Which genetic mutation is responsible for Iron-Refractory Iron Deficiency Anemia (IRIDA)?TMPRSS6BMP6HFEHJV30s
- Q4What is the expected response to oral iron therapy in patients with IRIDA?No or minimal responseNormal hemoglobin levelsComplete responseIncrease in iron absorption30s
- Q5How do elevated hepcidin levels affect iron absorption?They have no effectThey promote iron absorptionThey inhibit iron absorptionThey increase iron absorption30s
- Q6What laboratory finding is characteristic of IRIDA?High ferritin levelsElevated serum ironNormal transferrin saturationSevere hypoferremia with very low transferrin saturation30s
- Q7What is the mainstay of therapy for patients with IRIDA?Intermittent parenteral iron supplementationOral iron supplementationVitamin B12 injectionsBone marrow transplant30s
- Q8What is the purpose of the oral iron challenge test?To confirm hepcidin levelsTo measure hemoglobin levelsTo assess dietary iron intakeTo distinguish between intestinal iron absorption defect and other causes of iron deficiency30s
- Q9What potential therapeutic approach aims to suppress hepcidin levels?Anti-hepcidin antibodiesErythropoietinIron chelatorsVitamin C30s
- Q10What is a major clinical feature of untreated IRIDA?No clinical manifestationsSevere microcytosis and hypochromiaHigh reticulocyte countMacrocytic anemia30s
- Q11What would indicate a patient's hepcidin levels if they are diagnosed with IRIDA?VariableLowHigh only during infectionNormal-to-elevated30s
- Q12How does hepcidin affect ferroportin?By promoting its absorptionBy inhibiting its synthesisBy binding to it and causing its degradationBy increasing its expression30s
- Q13What clinical feature is indicative of untreated IRIDA?OrganomegalyElevated white blood cell countSevere microcytosis and hypochromiaHigh ferritin levels30s
- Q14What is an important diagnostic test for IRIDA?Bone marrow biopsyHepcidin serum level assayGenetic analysis of the TMPRSS6 geneLiver biopsy30s
- Q15What is the recommended initial treatment approach for IRIDA?Vitamin C aloneOral iron aloneParenteral iron supplementationBlood transfusion30s