Question 1

Which medication is commonly used as first-line treatment for Wilson disease?

Accepted Answer

D-penicillamine

Answer

Ammonium tetrathiomolybdate

Answer

Zinc acetate

Answer

Trientine

Question 2

Which of the following organs is primarily affected by Wilson disease?

Accepted Answer

Liver

Answer

Lungs

Answer

Heart

Answer

Kidneys

Question 3

Which specific neurological symptom is associated with Wilson disease?

Accepted Answer

Tremors

Answer

Seizures

Answer

Slurred speech

Answer

Numbness

Question 4

What is a common ocular finding in patients with Wilson disease?

Accepted Answer

Kayser-Fleischer rings

Answer

Chalazion

Answer

Conjunctival injection

Answer

Retinal detachment

Question 5

Which of the following is a common complication of untreated Wilson disease?

Accepted Answer

Liver cirrhosis

Answer

Diabetes

Answer

Hypertension

Answer

Hyperthyroidism

Question 6

In Wilson disease management, which of the following is often used to prevent copper absorption?

Accepted Answer

Zinc acetate

Answer

Iron supplements

Answer

Calcium carbonate

Answer

Vitamin D

Question 7

Which of the following laboratory findings warrants withdrawal of D-penicillamine therapy?

Accepted Answer

C. White blood cell count of 2,800/mm³

Answer

B. Neutrophil count of 2,200/mm³

Answer

A. Platelet count of 150,000/mm³

Answer

D. Hemoglobin level of 11.0 g/dL

Question 8

What is the primary role of zinc therapy in Wilson disease management?

Accepted Answer

C. Preventing re-accumulation of copper by reducing its absorption

Answer

A. Enhancing liver regeneration

Answer

B. Promoting copper excretion in bile

Answer

D. Increasing ceruloplasmin synthesis

Question 9

What is the typical daily maintenance dose of zinc acetate for adults with Wilson disease?

Accepted Answer

C. 150 mg in three divided doses

Answer

D. 200 mg in four divided doses

Answer

A. 50 mg once daily

Answer

B. 100 mg in divided doses

Question 10

Which chelator is associated with fewer neurologic side effects and is sometimes preferred over D-penicillamine?

Accepted Answer

C. Trientine

Answer

D. Ceruloplasmin

Answer

A. Zinc acetate

Answer

B. Ferritin

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