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Myeloproliferative disorders

Quiz by Wayne Aguiar

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20 questions
Show answers
  • Q1
    Myelodysplatic disorders are "best" characterized by
    increases in one specific cell line
    increase in cellular elements (RBC, WBC and/or platelets)
    decrease in cellular elements
    abnormal functioning cells
    30s
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  • Q2
    The primary defect in MPD
    megakaryoblast
    myelobast
    hematopoietic stem cell
    erythroblast
    30s
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  • Q3
    The feature(s) of MPD is/are
    transformation to acute leukemia
    hypercellular marrow with fibrosis
    extramedullary hematopoiesis
    all of the answers are correct
    30s
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  • Q4
    The most common transformation of CML is
    AML
    IMF
    ALL
    ET
    30s
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  • Q5
    What do ET, PV and CML all have in common
    transform to AML
    Are all MDS diseases
    transform to ALL
    transform to IMF
    30s
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  • Q6
    CML has
    two phases
    four phases
    three phases
    one phase
    30s
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  • Q7
    What statements are true for CML
    BCR-ABL gene fusion
    defect is called philadelphia chromosome
    all are true
    Chromosome 9 and 22 have a translocation
    30s
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  • Q8
    The terminal phase of CML is called
    acute phase
    chronic phase
    blast crisis
    aaccelerated phase
    30s
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  • Q9
    The advantage of using molecular techniques in CML
    Pinpoint detection of the translocation of Chromosome 9 and 22
    detect of PC
    detect alternate cases of PD found in ALL or AML
    detect ABR BCL gene fusion in absence of PC
    30s
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  • Q10
    Philadelphia chromosome is also found in
    Rare AML cases (2%)
    all of the above
    Childhood ALL (2-5%)
    Adult ALL (20%)
    30s
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  • Q11
    This is a picture consistent with
    Question Image
    CML
    CLL
    AML
    ALL
    30s
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  • Q12
    The cells at the tip of the arrows are best identified as
    Question Image
    lymphs
    myeloblasts
    Basophils
    eosinophils
    30s
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  • Q13
    Interpret the LAP stain, patient is on the right , control on the left
    Question Image
    Patient has Leukamoid reaction, decreased LAP
    Patient has Leukamoid reaection with a increased LAP
    Patient has CML, increased LAP
    Patient has CML, decreased LAP
    30s
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  • Q14
    What is true of CML therapy
    Question Image
    hydroxyurea is used
    all are true
    bone marrow transplant is used
    tyrosine kinase inhibitors are used
    30s
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  • Q15
    Which of the following is a MPD
    Essential thrombocythemia
    Polycythemia vera
    Chronic Idiopathic Myelofibrosis
    all of them
    30s
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  • Q16
    The primary defect in PV is
    ABR-BCL gene fusion
    Philadelphia Chromosome
    JAK 2 mutation
    all of the answers
    30s
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  • Q17
    The WHO definition of PV includes all but
    wbc > 12,000
    Hgb > 15g/dl males, Hgb > 14 g/dl females
    presence of JAK 2 in 90%
    platelets >400,000
    30s
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  • Q18
    A standard treatment for PV is
    Bone marrow transplant
    Hydroxyurea
    therapeutic phlebotomy
    EPO
    30s
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  • Q19
    The hall mark for ET is
    very low platelet counts
    extremely high platelet counts, large agranular
    abnormally small platelets
    splenomegaly and bleeding, or thrombosis
    30s
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  • Q20
    Chronic Idiopathic Myelofibrosis is also known as
    Agnogenic myeloid metaplasia
    all of the above
    Primary myelofibrosis Osteomyelofibrosis
    Myelofibrosis with myeloid metaplasia (MMM)
    30s
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