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What do an ancient Greek philosopher and a 19th century Quaker have in common with Nobel Prize-winning scientists? Although they are separated over 2,400 years of history, each of them contributed to answering the eternal question: what is stuff made of? It was around 440 BCE that Democritus first proposed that everything in the world was made up of tiny particles surrounded by empty space. And he even speculated that they vary in size and shape depending on the substance they compose. He called these particles "atomos," Greek for indivisible. His ideas were opposed by the more popular philosophers of his day. Aristotle, for instance, disagreed completely, stating instead that matter was made of four elements: earth, wind, water and fire, and most later scientists followed suit. Atoms would remain all but forgotten until 1808, when a Quaker teacher named John Dalton sought to challenge Aristotelian theory. Whereas Democritus's atomism had been purely theoretical, Dalton showed that common substances always broke down into the same elements in the same proportions. He concluded that the various compounds were combinations of atoms of different elements, each of a particular size and mass that could neither be created nor destroyed. Though he received many honors for his work, as a Quaker, Dalton lived modestly until the end of his days. Atomic theory was now accepted by the scientific community, but the next major advancement would not come until nearly a century later with the physicist J.J. Thompson's 1897 discovery of the electron. In what we might call the chocolate chip cookie model of the atom, he showed atoms as uniformly packed spheres of positive matter filled with negatively charged electrons. Thompson won a Nobel Prize in 1906 for his electron discovery, but his model of the atom didn't stick around long. This was because he happened to have some pretty smart students, including a certain Ernest Rutherford, who would become known as the father of the nuclear age. While studying the effects of X-rays on gases, Rutherford decided to investigate atoms more closely by shooting small, positively charged alpha particles at a sheet of gold foil. Under Thompson's model, the atom's thinly dispersed positive charge would not be enough to deflect the particles in any one place. The effect would have been like a bunch of tennis balls punching through a thin paper screen. But while most of the particles did pass through, some bounced right back, suggesting that the foil was more like a thick net with a very large mesh. Rutherford concluded that atoms consisted largely of empty space with just a few electrons, while most of the mass was concentrated in the center, which he termed the nucleus. The alpha particles passed through the gaps but bounced back from the dense, positively charged nucleus. But the atomic theory wasn't complete just yet. In 1913, another of Thompson's students by the name of Niels Bohr expanded on Rutherford's nuclear model. Drawing on earlier work by Max Planck and Albert Einstein he stipulated that electrons orbit the nucleus at fixed energies and distances, able to jump from one level to another, but not to exist in the space between. Bohr's planetary model took center stage, but soon, it too encountered some complications. Experiments had shown that rather than simply being discrete particles, electrons simultaneously behaved like waves, not being confined to a particular point in space. And in formulating his famous uncertainty principle, Werner Heisenberg showed it was impossible to determine both the exact position and speed of electrons as they moved around an atom. The idea that electrons cannot be pinpointed but exist within a range of possible locations gave rise to the current quantum model of the atom, a fascinating theory with a whole new set of complexities whose implications have yet to be fully grasped. Even though our understanding of atoms keeps changing, the basic fact of atoms remains, so let's celebrate the triumph of atomic theory with some fireworks. As electrons circling an atom shift between energy levels, they absorb or release energy in the form of specific wavelengths of light, resulting in all the marvelous colors we see. And we can imagine Democritus watching from somewhere, satisfied that over two millennia later, he turned out to have been right all along.

Grace Hopper (1906-1992): An American computer scientist and U.S. Navy rear admiral. She was a pioneer in computer programming and developed the first compiler for a computer programming language, laying the groundwork for cobol. Garrett Augustus Morgan Sr. (1877-1963): An African American inventor who patented the traffic signal and the safety hood, a precursor to the modern gas mask. Hedy Lamarr (1914-2000): An Austrian-American actress and inventor who co-invented an early technique for spread spectrum communications, a key to modern wifi and bluetooth technology. Otis Boykin (1920-1982): An African American inventor who patented over 25 electronic devices, including a control unit for the pacemaker that is widely used today. Stephanie Kwolek (1923-2014): An American chemist who invented the synthetic fiber Kevlar, which is used in bulletproof vests and other protective equipment. Gladys West (b. 1930): An African American mathematician who played a crucial role in the development of the GPS technology we use today. Shirley Ann Jackson (b. 1946): An African American physicist who was the first African American woman to receive a doctorate at MIT and her work laid the foundations for the touch-tone telephone, caller ID, and call waiting. Tu Youyou (b. 1930): A Chinese pharmaceutical chemist who discovered artemisinin, a drug therapy that has significantly reduced the mortality rates for malaria, for which she was awarded the Nobel Prize in Physiology or Medicine in 2015. Chien-Shiung Wu (1912-1997): A Chinese-American physicist who made significant contributions to the Manhattan Project and disproved the hypothetical law of conservation of parity, for which her male colleagues received the Nobel Prize (she did not). Mária Telkes (1900-1995): A Hungarian-American biophysicist and architect dubbed the "Sun Queen" for her pioneering work in solar energy, including the development of the first solar-powered house. Percy Lavon Julian (1899-1975): An African American chemist and pioneer in the chemical synthesis of medicinal drugs from plants. Charles Ginsburg (1925-1992): An American engineer who led the team that developed the first commercial videotape recorder. Philo Farnsworth (1906-1971): An American inventor who developed an electronic television system and made major contributions to early television technology. María Montoya Martínez (1887-1980): A Native American (Tewa) potter from San Ildefonso Pueblo, New Mexico, who helped revive the traditional black-on-black pottery style and is considered one of the most influential Pueblo potters of the 20th century. Satya Nadella (b. 1967): An Indian-American business executive who has been the chief executive officer of Microsoft since 2014, overseeing the company's transformation into a cloud computing powerhouse. Junko Tabei (1939-2016): A Japanese mountaineer who in 1975 became the first woman to reach the summit of Mount Everest, and the first woman to ascend the Seven Summits, climbing the highest peaks on each continent. Mildred Dresselhaus (1930-2017): An American physicist and engineer, known as the "Queen of Carbon Science," who made groundbreaking contributions to the study of carbon materials like graphite and carbon nanotubes. Ellen Ochoa (b. 1958): An American engineer and former astronaut. In 1993, she became the first Hispanic woman to go to space when she flew on the Space Shuttle Discovery. Françoise Barré-Sinoussi (b. 1947): A French virologist who co-discovered HIV as the cause of AIDS, for which she was awarded the Nobel Prize in Physiology or Medicine in 2008. Esther Lederberg (1922-2006): An American microbiologist who made significant contributions to genetics and microbiology, including the discovery of the bacterial virus lambda, but whose work was often overshadowed by her husband's Nobel Prize-winning accomplishments.

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