Osteoclasts Very large, multinucleated blood monocytes; ruffled border if active Located in depression of resorbed bone - Howship’s lacunae (aka resorption cavities) Function: bone resorption during bone growth and remodeling Digest collagen; dissolve calcium salt crystals Receptors for calcitonin (from thyroid gland) and for OSF (osteoclast-stimulating factor-1)
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8 questions
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- Q1What is the function of osteoclasts?Collagen synthesisBone formationCalcium absorptionBone resorption during bone growth and remodeling30s
- Q2Where are osteoclasts located?In the periosteumOn the surface of bonesIn depressions of resorbed bone - Howship’s lacunae (aka resorption cavities)In the bone marrow30s
- Q3What is the characteristic feature of active osteoclasts?Spiked edgesRuffled borderIrregular shapeSmooth surface30s
- Q4Which hormones can stimulate osteoclast activity?Estrogen and testosteroneThyroxine and parathyroid hormoneCalcitonin and osteoclast-stimulating factor-1 (OSF-1)Growth hormone and insulin30s
- Q5What is the primary type of cell involved in bone resorption?OsteoblastsChondrocytesFibroblastsOsteoclasts30s
- Q6Which cells are responsible for digesting collagen and dissolving calcium salt crystals in bone?OsteoclastsChondrocytesOsteoblastsOsteocytes30s
- Q7Which of the following is a characteristic feature of osteoclasts?BinucleatedMultinucleatedTrinucleatedUninucleated30s
- Q8What is the main function of osteoclasts in bone remodeling?Collagen productionBone formationMineralizationBone resorption30s