Question 1

Which cells lay down bone matrix on the septa of cartilage matrix during bone development?

Accepted Answer

Osteoblasts

Answer

Osteoclasts

Answer

Fibroblasts

Answer

Chondrocytes

Answer

Osteoprogenitor cells

Question 2

What is the function of the periosteal bud in bone development?

Accepted Answer

To bring osteoprogenitor cells & osteoblasts which lay down bone (woven) matrix on septa of cartilage matrix

Answer

To replace cartilage with bone along the diaphysis

Answer

To produce chondrocytes in the growth plate

Answer

To resorb calcified cartilage/bone complex and enlarge cavity

Answer

To compress and calcify the matrix of trabeculae

Question 3

What is the main function of chondrocytes in bone development?

Accepted Answer

To enlarge, compress matrix (into trabeculae), calcify matrix (release enzymes and osteocalcin), die & leave large empty lacunae (cavity)

Answer

To resorb calcified cartilage/bone complex and enlarge cavity

Answer

To replace cartilage with bone along the diaphysis

Answer

To produce chondrocytes in the growth plate

Answer

To bring osteoprogenitor cells & osteoblasts which lay down bone matrix on septa of cartilage matrix

Question 4

What is the role of osteoprogenitor cells in bone development?

Accepted Answer

To differentiate into osteoblasts and participate in bone formation

Answer

To lay down bone matrix on the septa of cartilage matrix

Answer

To resorb calcified cartilage/bone complex and enlarge cavity

Answer

To enlarge and compress the matrix into trabeculae

Answer

To produce chondrocytes in the growth plate

Question 5

What happens to the empty lacunae left by chondrocytes during bone development?

Accepted Answer

They fill with bone marrow

Answer

They are resorbed by osteoclasts

Answer

They are filled with cartilage matrix

Answer

They calcify and harden

Answer

They remain empty and serve as structural support

Question 6

What is the process by which bone replaces cartilage along the diaphysis?

Accepted Answer

Endochondral ossification

Answer

Intramembranous ossification

Answer

Epiphyseal growth

Answer

Periosteal apposition

Answer

Cartilage remodelling

Question 7

What is the function of osteoblasts in bone development?

Accepted Answer

To lay down bone matrix on the septa of cartilage matrix

Answer

To enlarge and compress the matrix into trabeculae

Answer

To produce chondrocytes in the growth plate

Answer

To resorb calcified cartilage/bone complex and enlarge cavity

Answer

To bring osteoprogenitor cells & osteoblasts which lay down bone matrix on septa of cartilage matrix

Question 8

What is the function of osteoclasts during bone development and remodeling?

Accepted Answer

To resorb bone and facilitate bone resorption

Answer

To compress and calcify the matrix of trabeculae

Answer

To bring osteoprogenitor cells & osteoblasts for bone formation

Answer

To produce chondrocytes in the growth plate

Answer

To lay down bone matrix on the septa of cartilage matrix

Question 9

What is the term used to describe the process of bone formation directly from mesenchymal cells without a cartilage intermediate?

Accepted Answer

Intramembranous ossification

Answer

Epiphyseal growth

Answer

Periosteal apposition

Answer

Cartilage remodelling

Answer

Endochondral ossification

Question 10

What is the primary function of osteoclasts in bone development?

Accepted Answer

To resorb calcified cartilage/bone complex and enlarge cavity which fills with bone marrow

Answer

To replace cartilage with bone along the diaphysis

Answer

To produce chondrocytes in the growth plate

Answer

To lay down bone matrix on the septa of cartilage matrix

Answer

To compress and calcify the matrix of trabeculae

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