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Pyrogen and endotoxin test

Quiz by KARINA CITRA RANI _

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50 questions
Show answers
  • Q1
    Which organism is commonly used in the Limulus Amebocyte Lysate (LAL) test?
    Horseshoe crab
    Starfish
    Seahorse
    Jellyfish
    30s
  • Q2
    What is the main source of endotoxins in the human body?
    Parasites
    Gram-negative bacteria
    Fungi
    Gram-positive bacteria
    30s
  • Q3
    Which of the following is a common symptom of pyrogenic response?
    Headache
    Muscle soreness
    Fever
    Cough
    30s
  • Q4
    What is the principle behind the Pyrogen test?
    Determining cellular response
    Identifying genetic mutations
    Measuring antibody levels
    Detecting fever-causing substances
    30s
  • Q5
    What is pyrogen separation?
    A process to add pyrogens to pharmaceutical products
    A process to sterilize pharmaceutical products
    A process to remove pyrogens from pharmaceutical products
    A process to test the presence of pyrogens in pharmaceutical products
    30s
  • Q6
    What is the primary source of pyrogens in pharmaceutical products?
    Improper storage conditions
    Contaminated raw materials
    Manufacturing equipment
    Human error during production
    30s
  • Q7
    Why is pyrogen separation important in the pharmaceutical industry?
    To prevent adverse reactions in patients
    To enhance the color and appearance of products
    To minimize the cost of production
    To increase the shelf life of products
    30s
  • Q8
    What are some common methods used for pyrogen separation in pharmaceutical production?
    Chemical disinfection
    Freezing and lyophilization
    Radiation sterilization
    Filtration and depyrogenation ovens
    30s
  • Q9
    What is the purpose of endotoxin testing in pyrogen separation?
    To determine the efficacy of pyrogen removal methods
    To assess the product's stability over time
    To test the pH level of the product
    To ensure the absence of bacterial contamination
    30s
  • Q10
    Which regulatory agency sets guidelines for pyrogen separation in the pharmaceutical industry?
    CDC (Centers for Disease Control and Prevention)
    WHO (World Health Organization)
    EMA (European Medicines Agency)
    FDA (Food and Drug Administration)
    30s
  • Q11
    What are some common symptoms of pyrogenic reactions in patients?
    Fever, chills, and inflammation
    Skin rash, itching, and hives
    Dizziness, fatigue, and headache
    Nausea, vomiting, and diarrhea
    30s
  • Q12
    What is the defined limit for endotoxin levels in pharmaceutical products?
    1 microgram per milliliter (µg/mL)
    Depends on the product and route of administration
    10 parts per million (ppm)
    100 parts per billion (ppb)
    30s
  • Q13
    Which of the following is NOT a method for pyrogen separation in pharmaceutical production?
    Depyrogenation ovens
    Radiation sterilization
    Filtration
    Chemical disinfection
    30s
  • Q14
    What is the purpose of the Limulus Amebocyte Lysate (LAL) test in endotoxin measurement?
    To determine bacterial growth
    To identify viral contaminants
    To measure pH levels in a sample
    To detect the presence of endotoxins
    30s
  • Q15
    What is the purpose of an endotoxin test?
    To detect bacterial contamination
    To measure pH levels
    To identify viral infections
    To determine toxin levels
    30s

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