Thrombocytosis
Quiz by Sadeq K. Ali Al-Salait
Feel free to use or edit a copy
includes Teacher and Student dashboards
Measure skillsfrom any curriculum
Tag the questions with any skills you have. Your dashboard will track each student's mastery of each skill.
- edit the questions
- save a copy for later
- start a class game
- automatically assign follow-up activities based on students’ scores
- assign as homework
- share a link with colleagues
- print as a bubble sheet
- Q1
Which of the following is NOT a category of thrombocytosis?
Infectious
Clonal
Reactive
Spurious
30s - Q2
What is a common characteristic of spurious thrombocytosis?
Increased megakaryocyte production
Laboratory artifact
Autosomal dominant inheritance
Elevated serum IL-6levels
30s - Q3
Which cytokine is predominantly elevated in reactivethrombocytosis (RT)?
IL-1
IL-6
IL-3
TNF-α
30s - Q4
Familial thrombocytosis is characterized by again-of-function mutation in which gene?
JAK2
CALR
TPO or c-MPL receptorgene
TET2
30s - Q5
What percentage of patients with polycythemia vera (PV)present with thrombocytosis?
30%
90%
50%
10%
30s - Q6
What is a major cause of morbidity and mortality in patients with clonal thrombocytosis, especially in ET and PV?
Vasomotor symptoms
Microvascular inflammation
Thrombotic complications
BM failure syndrome
30s - Q7
Which treatment is typically NOT recommended for reactive thrombocytosis?
Monitoring and treating the underlying cause
Cytoreductive therapy
Antiplatelet therapy
Plateletpheresis
30s - Q8
Which of the following cytokines is NOT typically elevatedin reactive thrombocytosis (RT)?
IL1
IL6
IL2
IL3
30s - Q9
What laboratory findings would support a diagnosis ofreactive thrombocytosis (RT) over clonal thrombocytosis?
increased RBC count
Elevated serum IL-6and C-reactive protein levels
Presence of JAK2V617F mutation
Elevated TPO levels
30s - Q10
Which mutation is most commonly associated with essential thrombocythemia (ET) and is absent in familial thrombocytosis?
MPL exon 10
TET2
JAK2 V617F
CALR
30s - Q11
What is the primary role of the peripheral blood smear inthe diagnosis of thrombocytosis?
To determine megakaryocyte production levels
Platelet morphology
presence of blast or immature cells
To confirm the platelet count and identify non-platelet artifacts
30s - Q12
What is the significance of finding elevated TPO levels inboth reactive and clonal thrombocytosis?
It is a diagnosticcriterion for essential thrombocythemia
It suggests a physiological feedback mechanism
It differentiates between the two conditions
It indicates a common underlying genetic mutation
30s - Q13
In the context of thrombocytosis, what is acquired vonWillebrand syndrome (AVWS) primarily caused by?
Decreased degradation of vWF
Increased productionof vWF multimers
Increased adsorptionof large vWF multimers onto platelets
Genetic mutation inthe vWF gene
30s