According to the video, what is the central dogma of molecular biology?

The process of transcription and translation

The formation of proteins from RNA

The different types of genetic mutations

The storage of genetic information in the form of DNA

What is the main difference between point mutations and frame-shift mutations?

Point mutations change one DNA base, whileframe-shift mutations add or delete bases

Point mutations lead to missense mutations, while frame-shift mutations lead to non-sense mutations

Point mutations affect the DNA structure, while frame-shift mutations affect the resulting protein

Point mutations result in conservative mutations, while frame-shift mutations result in nonconservative mutations

How are non-sense mutations and missense mutations different?

Non-sense mutations change an amino acid from one to another, while missense mutations create a stop codon

Non-sense mutations can be further divided into silent mutations, conservative mutations, and nonconservative mutations

Non-sense mutations affect the protein more than missense mutations

Non-sense mutations are classified based on their effects on DNA, while missense mutations are classified based on their effects on protein

How is sickle cell disease classified?

Nonconservative missense mutation

What is the most important learning to be drawn from the video?

How mutations affect the protein level

The different types of genetic mutations

The central dogma of molecular biology

How mutations originate at the DNA level

How are mutations classified?

Based on their effects on protein

TYPES OF CLONING (ASYNC 10-23) RETAKE

Camshaft: A rotating shaft in an engine that controls the opening and closing of the intake and exhaust valves. Aftercooler (air to air): A device that cools the compressed air from a turbocharger using outside air. Glow Plugs: Heating elements used to aid in starting diesel engines in cold temperatures. Timing Cover: The cover that protects the timing gears and belt or chain in an engine. Exhaust Manifold: A component that collects exhaust gases from multiple cylinders and directs them to the exhaust pipe. Oil Suction Tube: A tube that draws oil from the oil pan to the oil pump. Air Compressor: A device that increases the pressure of air and is often used to power air brakes or pneumatic tools. Oil Cooler: A device that cools the engine oil, helping prevent it from overheating. Supercharger/Blower: A device that increases the pressure of the air-fuel mixture entering the engine to boost power. Piston Rings: Rings around the piston that seal the combustion chamber, control oil consumption, and conduct heat. Crankshaft: A shaft that converts the linear motion of the pistons into rotational motion to power the vehicle. Oil Pan: A reservoir at the bottom of the engine that collects and holds the engine oil. Connecting Rod: Connects the piston to the crankshaft, converting the piston's motion into rotational motion. Stroke: The distance the piston travels within the cylinder, from top dead center to bottom dead center. 2 Cycle: A type of engine that completes a power cycle in two strokes of the piston. Crankshaft Main Bearing: The bearing that supports the crankshaft in the engine block. Aftercooler (water/coolant): A device that cools the compressed air from a turbocharger using water or coolant. Water Pump: A pump that circulates coolant through the engine and radiator to prevent overheating. Oil Filter: A filter that removes contaminants from the engine oil. Vibration Dampener: A device attached to the crankshaft to reduce engine vibrations. Piston Wrist Pin: The pin that connects the piston to the connecting rod. Valve Cover: The cover that protects the engine's valves and camshaft. Cylinder Block: The main structure of an engine that houses the cylinders and other components. ECM/ECU: Electronic Control Module or Electronic Control Unit, which controls various engine functions. Cylinder Head: The top part of the cylinder that contains the combustion chamber, valves, and spark plugs. Oil Pump: A pump that circulates oil through the engine to lubricate moving parts. Cylinder Liner: A sleeve inside the cylinder that protects it from wear and corrosion. TDC (Top Dead Center): The highest position the piston reaches in its stroke. Bore: The diameter of a cylinder in an engine. Flywheel: A heavy wheel that stores rotational energy to smooth out engine operation. Crankshaft Rod Bearing: The bearing that connects the crankshaft to the connecting rod. Push Tube / Push Rod: Rods that transmit motion from the camshaft to the valves. Piston: A cylindrical component that moves up and down within the cylinder to create power. Flywheel Housing: The casing that surrounds and supports the flywheel. Valve Lifter or Cam Follower: A component that follows the camshaft lobes to open and close the valves. Turbo: A device that increases the engine’s power by forcing more air into the combustion chamber. Intake & Exhaust Valves: Valves that control the intake of air and the exhaust of gases in the engine. Intake Manifold: A manifold that distributes the air-fuel mixture or air to the cylinders. Rocker Arm: A lever that transfers camshaft motion to the valves. Wastegate: A valve that controls the exhaust gases flowing to the turbocharger, preventing excessive boost pressure. Fuel Injector: A device that sprays fuel into the combustion chamber. Fuel Pump: A pump that moves fuel from the fuel tank to the engine. BDC (Bottom Dead Center): The lowest position the piston reaches in its stroke. 4 Cycle: A type of engine that completes a power cycle in four strokes (intake, compression, power, exhaust). Articulated Piston: A piston with two pieces (crown and skirt) joined by a pivot, allowing some flexibility in movement.

Stages in the Sale of a Property Stage 1 – Getting to Instruction • Initial contact with the vendor: need to check the following: type of property, contact details of vendor, address of property/Eircode and purpose of the contact - sale or valuation? If a sale, does the vendor need a quick sale? Qualify the lead i.e. is the vendor buying another property? If an investment property, is the tenant in situ? Check if there is a folio number available and confirm the ownership of the property. Schedule the viewing. • Pre-viewing: Set up a file & record all info from initial contact on CRM system. Check the Property Price Register to help get a general idea of property valuation (subject to viewing, helps to display knowledge of area/market and set expectations for the vendor). Nature of property may affect pricing e.g. starter home vs. larger property with vendor seeking to downsize. Consideration for comparables may include similar/same location, size and condition of property, availability and type of parking, layout of property, plot size, orientation of garden, extensions undertaken etc. Nature of market conditions, state of wider economy, cost of capital and availability of credit may also be factors. • Appraisal/viewing: Bring an advertising pack/sales & marketing brochures. Walk through property with client, note nice features/selling points for the brochure, let the client talk about upgrades/specific features of the property. It is very important to listen to the vendor and build rapport. Confirm property details e.g. condition and layout, plot size, orientation of garden. Check for certificates of compliance for any extensions, planning permissions for conversions, right of way if applicable etc. Check if a BER available/provide details for approved assessors. Demonstrate your/the practice’s professional expertise, justify why you should get the instruction, discuss recent local sales and give your potential valuation. Discuss the sales fee, marketing fee and any additional charges e.g. professional photography, drone footage, virtual tours (walkthrough video, Matterport etc.) Ask how the vendor heard about you/your practice and why are they considering you for the sale. Where appropriate offer advice to help vendor increase potential sales price. (If possible, leave with signed Property Services Agreement/Letter of Engagement.) Thank you, send/email market appraisal, any queries/questions do get in touch and let the vendor know that we’ll be in touch in coming days. • Post appraisal – letter sent that pm/next morning with market appraisal; diary note to follow up. Check that market appraisal letter received and check for questions. If did not get sale, find out why not/debrief. If get the sale, email confirmation of instruction. Once PSRA sent and LOE returned signed = stage 2. Other details required – ID, proof of address, proof of ownership/title, solicitor details, BER certificate (refer to assessor if not available). All these should be uploaded to CRM. Stage 2 – Getting to ‘Sale Agreed’ Set up appointment to measure & photograph, note any special features e.g., upgraded kitchen, south-facing garden. Provide ideas for improving sales potential (declutter, painting, tidy garden etc. Check if has vendor potential buyers in mind already e.g., relations, friends, other parties interested. Seek vendor approval for photos/text of brochure. Check for access (tenants in situ/working from home etc) and confirm viewing times. If given a key for viewings – tag it! Check alarm codes & whether a sign is allowed on the property. Bring to market – upload to all websites e.g., daft/my home, in house websites and create window display. Match the property against your internal database of potential purchasers /CRM system. Set up appointments for viewings on CRM or arrange for open viewings. Confirm viewings with vendor & purchaser. Turn on lights, open windows, secure valuables, leave out brochures & business cards, bring viewings sheets to keep record of attendees. Introduce yourself and get attendee details. Let people view the property and address any questions. Point out key features. Record questions to be answered and any feedback from viewers. Ask are they selling property? Let viewers know of offers already received. Lock up/alarm property/close windows. Provide vendor with feedback on viewings - number of viewers / questions raised/overall reaction to property. Offers should be confirmed in writing & upload to on CRM/ offers will be input by bidders onto online bidding platforms ‘Proof of funds’ required for offers in some practices. Successful bidder will be chosen by vendor, who might want quick sale/no chain or prefer the highest bidder. Booking deposit will be sought from successful bidder. The amount varies by practice but must cover fees. Sales Advice Notice/letter should be sent to both solicitors (and may be cc’d to vendor/buyer or notify both that SAN have gone out). Booking deposit receipt should be issued. The BER certificate and report should go to the solicitor. Send requests for docs/info to successful bidder including steps they need to take to progress sale e.g., organise the bank valuation and/or schedule the survey. Once the deposit is paid the property is Sale Agreed, inform other bidders, and update all websites/sales board etc. Stage 3 – Getting to closing Access should be organised for the bank valuation/survey. Stay in touch with both solicitors ‘contract-chasing’ i.e., check when contracts are issued, signed and queries answered. Legal searches undertaken by the solicitors may include checking boundaries, land registry, title, rights of way, compliance certs etc. When contracts are signed 10% purchase price/booking deposit should be sent to the vendor’s solicitor. Once all queries satisfied = drawdown of mortgage/funding, house/life insurance in place. Title deeds will be requested once contract is signed. Decide final closing date. Check that the property taxes have been paid. Check that vendor has vacated the property. When vacant, conduct the final walkthrough and take final readings (MPRNs ). Check with solicitor if the drawn down funds h, and once received the solicitor gives authorisation to the estate agent to release the keys. The agent will do up invoice, send the balance of funds to solicitor and provide gift to purchaser. Finally remove sign, mark as sold on CRM, seek testimonials, upload to social media and close a/c on CRM

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