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Zones in epiphyseal cartilage (regions of cellular activity) Zone 1: Zone of Resting cartilage Zone 2: Zone of proliferating cartilage Chondrocytes aligned as aggregates in lacunae Zone 3:Zone of hypertrophic cartilage Cells enlarge; matrix compressed into bands Zone 4: zone of calcified cartilage Cells calcify the matrix (hydroxyapatite crystals formed); undergo apoptosis Zone 5: Zone of ossification Vessels invade region; osteoblasts deposit osteoid on calcified spicules of cartilage forming woven bone; remodeled as lamellar bone | Quizalize