Which of the following is NOT a 1st gen ("typical") antipsychotic

Which of the following is NOT a HIGH POTENCY 1st gen antipsychotic

Which of the following is NOT a 2nd gen ("atypical") antipsychotic

All antipsychotics ANTAGONIZE the D2 dopamine receptor in the  ____________________ pathway

In addition to the D2 dopamine receptor, 2nd generation antipsychotics also ANTAGONIZE ___________ more strongly than 1st generation (which may contribute to their inhibition of positive symptoms)

The most severe type of psychosis is

Which of the following are considered "negative" symptoms of schizophrenia

Which of the following are considered "positive" symptoms of schizophrenia

APDs are generally defined as 1st generation ____________ or 2nd generation _____________

Inhibition of the mesocortical domaminergic pathway is responsible for the therapeutic effects of 1st and 2nd generation APDs

The higher the D2 receptor affinity the ___________ the clinically effective dose

Therapeutic response can be achieved with ______% D2 receptor occupancy

Inhibition of serotonin signaling, possibly in __________ is thought to contribute to APD effects

Increased serotonin signaling in the PFC contributes to hallucinations and delusion resulting from

Extrapyramidal symptoms result from antagonism of the D2 receptors in non-therapeutic dopamine pathways. These effects are MORE prominent with which generation

EPS involve loss of control of skeletal muscle movement and are related to all of the following except

Inhibition of which pathway is responsible for hormonal symptoms of APDs

Toxicities - Hormonal changes result from antagonism of D2 receptors in non-therapeutic dopamine pathways and are LESS prominent with

Inhibition of which pathway is responsible for EPS symptoms of APDs

Hyperprolactinemia has potential secondary effects including all of the following except

Neuroleptic malignant syndrome is a rare toxicity that is more common with

Muscle rigidity and hyperthermia associated with neuroleptic malignant syndrome may be treated with

Metabolic syndrome may result from antagonism of ___________________ and is more prominent in _____ generation drugs

Metabolic syndrome involves having 3/5 of which symptom set

2nd generation drugs cause more weight gain in general than 1st generation drugs

Sedation is common with low-potency 1st gen and 2nd gen drugs due to antagonism of which receptors

Anticholinergic/parasympathetic effects are common with low-potency 1st gen and 2nd gen drugs due to antagonism of which receptors

Orthostatic hypotension is common with low-potency 1st gen and 2nd gen drugs due to antagonism of which receptors

Prolonged QT is most common with

Prolonged QT is due to blockade of which of the following

In addition to APDs which can lead to prolonged QT which drugs also can?

Clozapine (2nd gen) toxicity