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Immunodeficiency for USMLE step 1 WUHS

Quiz by Mohammad Ghosheh

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11 questions
Show answers
  • Q1
    What is the most common primary immunodeficiency disorder?
    DiGeorge syndrome
    Common variable immunodeficiency
    Selective IgA deficiency
    X-linked agammaglobulinemia
    30s
  • Q2
    What is the mechanism of action of rituximab in the treatment of immunodeficiency?
    Stimulation of antibody production
    Inhibition of cytokine production
    Activation of T cells
    Depletion of B cells
    30s
  • Q3
    Which of the following is not a symptom of severe combined immunodeficiency (SCID)?
    Chronic diarrhea
    Failure to thrive
    Persistent fungal infections
    Hyperreactive immune response
    30s
  • Q4
    Which of the following is a characteristic feature of Wiskott-Aldrich syndrome?
    Recurrent bacterial infections
    Thrombocytopenia
    Decreased IgG levels
    Eczema
    30s
  • Q5
    Which of the following is a secondary immunodeficiency disorder?
    HIV/AIDS
    DiGeorge syndrome
    Common variable immunodeficiency
    X-linked agammaglobulinemia
    30s
  • Q6
    Which of the following is true regarding Bruton tyrosine kinase deficiency?
    It affects T cell development
    It affects plasma cell function
    It affects natural killer cell function
    It affects B cell development
    30s
  • Q7
    What is the mechanism of action of glucocorticoids in immunosuppression?
    Stimulation of antibody production
    Depletion of B cells
    Inhibition of cytokine production
    Stimulation of T cell activity
    30s
  • Q8
    Which complement component deficiency is associated with an increased risk of Neisseria infections?
    Factor I
    C5-C9
    C1-C4
    Factor H
    30s
  • Q9
    What is the inheritance pattern of X-linked hyper-IgM syndrome?
    Mitochondrial inheritance
    Autosomal dominant
    X-linked recessive
    Autosomal recessive
    30s
  • Q10
    Which of the following is NOT a feature of DiGeorge syndrome?
    Hypoparathyroidism
    Thymic hypoplasia
    High serum levels of IgE
    Cardiac anomalies
    30s
  • Q11
    Which viral infection is associated with an increased risk of developing lymphoma in patients with immunodeficiency?
    Coronavirus
    Epstein-Barr virus
    Rhinovirus
    Influenza virus
    30s

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