
Chem Midterm 2
Quiz by Lauren Phoenix
Tag the questions with any skills you have. Your dashboard will track each student's mastery of each skill.
the ______ ribozyme self cleaves phosphodiester bond
______ DNA attacks mRNA directly and can be used as a RNA-degrading therapeutic
in duchenne muscular distrophy patients ______ ______ can be used to make a shortened version of the distrophin protein
a tRNA carries the ____
all amino acids are ____ position
in amino acids, the nucleophile is _____
the 3' end of tRNA is _____
amide bond formation requires _______ the acid, because it is not a _____ _____ _____
_____ is a good H bond acceptor and donor, and is very stable
_____ is used in mRNA based vaccines
Type 1 tRNA synthetase transfer to ____' hydroxyl and type 2 to ____'
________ is a bad leaving group
there is ____ synthetase for each amino acid
____ is also a start codon
Which is false of TGF-beta
Which is false of ribosomes
the ______ site is a nucleophile
the ______ site is an electrophile
________ stop syntheis of peptide by recognizing stop codon and bringing H2O as a nucleophile
______ physically blocks the exit tunnel to stop protein synthesis
_____ _____ are proteins responsible for proper tRNA loading
if correct tRNA is encountered by EF-1alpha, hydrolysis of ____ to ___ occurs
EF-1beta is responsible for
how does ricin shut down synthesis in the sarcin-ricin loop
______ has a pka of 5.5 so is a good nucleophile because it can be deprotonated at neutral pH
the _____ _____ has high atom economy,tolerates mild conditions and is highly selective
______ means it does not react with naturally occuring functional groups in biology
______ are RNA or DNA sequences that bind specific target (protein or small molecule)
______ can take any kind of activated amino acid and load it on tRNA
peptides are directional, read ____ to _____
a ______ has a seperate positive and negative charged groups, amino acids are these
If pKa is less than pH, henderson hasselbalch ratio is ____ than 1 and is _______
If pKa is greater than pH, henderson hasselbalch ratio is ____ than 1 and is _______
3 hydrophobic interactions
2 polar interactions
_____ is added at N terminus and _____ at C terminus
5'OH is a better nucleotide because
when carbodiimide is used _____ is the leaving group
in peptide synthesis ____ is acid labile protecting group and _____ is base labile
the solid for peptide synthesis is _____ _____ resin
You need a _____ to cleave peptide from resin, so ______ protecting group has risk of some being cleaved
the advantage to peptide nucleic acid
____ _____ _____ forms a new bond between exteins, cysteine does N-S acyl transfer
a ______ group blocks reactivity of a site and can be removed later
a ______ group makes a molecular fragment reactive