Question 1

What is the most common cause of HDFN today?

Accepted Answer

ABO incompatibility

Answer

Anti-D alloimmunization

Answer

Anti-M antibodies

Answer

Kell antigen incompatibility

Answer

RhC incompatibility

Question 2

Which immunoglobulin class is responsible for HDFN?

Accepted Answer

IgG

Answer

IgD

Answer

IgE

Answer

IgM

Answer

IgA

Question 3

Which maternal blood group is most likely to cause severe ABO HDFN?

Accepted Answer

Group O

Answer

Group A

Answer

Group A2

Answer

Group B

Answer

Group AB

Question 4

What is the most antigenic RBC antigen involved in HDFN?

Accepted Answer

RhD

Answer

S

Answer

P1

Answer

Kell

Answer

Jk(a)

Question 5

What is the primary reason ABO HDFN tends to be less severe than RhD HDFN?

Accepted Answer

A and B antigens are underdeveloped on fetal RBCs

Answer

ABO antibodies are not IgG

Answer

RhD antibodies are neutralized by fetal spleen cells

Answer

Fewer maternal antibodies are produced

Answer

ABO antibodies are blocked by maternal immune cells

Question 6

Which maternal antibodies are the most efficient in causing RBC destruction?

Accepted Answer

IgG1 and IgG3

Answer

IgM

Answer

IgG2 and IgG4

Answer

IgG2 and IgM

Answer

IgA1 and IgA2

Question 7

What is the primary diagnostic test for HDFN after birth?

Accepted Answer

Direct antiglobulin test (DAT)

Answer

Complete blood count

Answer

Reticulocyte count

Answer

Blood group typing

Answer

Serum bilirubin

Question 8

What blood group characteristics are essential for intrauterine transfusion (IUT) units?

Accepted Answer

Group O, RhD-negative, and leukocyte-reduced

Answer

AB-positive and irradiated

Answer

Fresh frozen plasma-compatible

Answer

AB-negative and crossmatched with maternal blood

Answer

RhD-negative and CMV-tested

Question 9

Which maternal antibody is associated with a higher risk of severe fetal anemia even at low titers?

Accepted Answer

Anti-Kell

Answer

Anti-M

Answer

Anti-Duffy

Answer

Anti-Jk(b)

Answer

Anti-Lewis

Question 10

How does Rh immune globulin (RhIG) prevent maternal alloimmunization? What is the most likely mechanism?

Accepted Answer

Prevents B-cell priming against RhD antigens

Answer

Blocks antigen-antibody interactions

Answer

Increases IgG production

Answer

Neutralizes circulating fetal RBCs

Answer

Suppresses maternal immune system

Question 11

What is the main indication for exchange transfusion in HDFN?

Accepted Answer

Critical hyperbilirubinemia

Answer

Hypoglycemia

Answer

Severe anemia

Answer

Poor feeding

Answer

Hypothermia

Question 12

What is a significant contraindication for administering RhIG to a mother?

Accepted Answer

Mother already actively immunized against RhD

Answer

Maternal anemia

Answer

ABO incompatibility

Answer

Hydrops fetalis

Answer

Positive indirect Coombs test

Related quizzes

Related quizzes