Question 1

Which statement accurately describes the relationship betweendrug particle size and solubility?

Accepted Answer

C. As drug particle size decreases, the surface area increases, which intrinsically enhances solubility.

Answer

B. Increasing drug particle size leads to a greater surface area and acorresponding increase in solubility.

Answer

D. Decreasing particle size has no significant impact on the drug's solubilityor surface area.

Answer

A. Decreasing particle size often reduces the drug's surface area, therebyincreasing its solubility.

Question 2

Micronization is a process that reduces drug particle size to whattypical range?

Accepted Answer

Micrometer range (1-10 µm)

Answer

.Millimeter range (1-10 mm)

Answer

Angstrom range (1-10 Å)

Answer

Nanometer range (1-10 nm)

Question 3

How does micronization enhance the dissolution rate of a drug,according to the Noyes-Whitney equation?

Accepted Answer

The dissolution rate becomes directly proportional to the increasedsurface area from smaller particles.

Answer

It alters the chemical structure of the drug, leading to faster breakdown inthe dissolution medium.

Answer

It increases the drug's intrinsic solubility, making it less dependent onsurface area.

Answer

It decreases the particle surface area, slowing down the dissolutionprocess

Question 4

Which micronization method is suitable for heat-sensitivematerials and minimizes contamination due to the absence ofmoving parts?

Accepted Answer

Jet Milling, utilizing high-speed streams of compressed gas.

Answer

Ball Milling, relying on impact and grinding with rotating media.

Answer

A combination of both Ball Milling and Jet Milling for optimal results.

Answer

Cryogenic Grinding, which typically introduces liquid nitrogen as acoolant.

Question 5

What is a significant advantage of nanocrystals over micronized particles regarding surface area?

Accepted Answer

Nanocrystals expose a larger surface area compared to micronizedparticles, enhancing dissolution.

Answer

Nanocrystals primarily improve solubility by increasing particle density,not surface area

Answer

C. Nanocrystals exhibit a similar surface area to micronized particles but with better uniformity.

Answer

Nanocrystals have a smaller total surface area, which improves stability.

Question 6

Why do nanocrystals often require stabilizers like surfactants orpolymers in their formulations?

Accepted Answer

To prevent aggregation and Ostwald ripening due to their very highsurface energy.

Answer

To decrease their dissolution rate by creating a protective barrier

Answer

To enhance their pharmacological activity by interacting directly withbiological targets.

Answer

To increase their overall particle size and reduce surface energy.

Question 7

What is the primary purpose of forming cocrystals forpharmaceutical applications?

Accepted Answer

To modify physical properties like solubility and stability without altering pharmacological activity.

Answer

To alter the pharmacological activity of the drug.

Answer

To change the chemical structure of the drug for improved potency.

Answer

To increase the drug's particle size for easier handling

Related quizzes