A 50 yo patient presents with seizures, headaches and focal neuro deficits. What does he have?

Which of the following types of tumors has increased cellularity and nuclear pleomorphism

Which of the following types of tumors is typically seen in children and young adults, has benign behavior, and on microscopy has bipolar cells with hair-like processes as well as rosenthal fibers?

Which of the following has serpentine pattern with malignant cells crowding the edges, giving a pseudopalisading appearance as well as glomeruloid body?

Which of the following shows increased mitotic activity, LOH 1p and 19q, and appears grossly as a well-circumscribed gelatinous-like gray mass?

Which of the following is characterized by hydrocephalus (from 4th ventricle obstruction), perivascular pseudorosettes, GFAP+, and mutations involving chromosome 22 in 10-20 yo?

Which of the following is typically in children with a loss of 17p (neurotrophin receptor) located midline of the cerebellum, shows anaplastic cells and subarachnoid infiltration, is highly malignant, and is radiosensitive?

Which of the following is a benign tumor, seen in people with a first degree relative with NF-2 who had a unilateral vestibular schwannoma and is characterized by well-defined dural base with psammoma bodies?

Which type of meningioma is highly aggressive and can infiltrate brain parenchyma?

15 yo male with progressive history of severe headaches, visual disturbances and prominent vessels in temporal regions. On CT Scan, an enhancing intraventricular tumor is seen as well as expansion of IV ventricle. What is the most likely diagnosis?

A 63 yo man with seizures, headache, spasms and weakness of right upper and lower extremities. CT Scan shows an irregular enhancing ring lesion involving the left parietal lobe and associated edema. Neurosurgery recommends craniotomy and resection of tumor followed by radiation and chemotherapy. The pathology report shows pseudopalisading arrangements. What is the most likely diagnosis?

A 12 yo girl presents to the ER with clumsiness, poor handwriting, unsteady gait and headache developing over the last few months. Patient now dehydrated secondary to frequent morning emesis. CT Scan shows a large enhancing lesion posterior to the 4th ventricle within the Vermis and behind Pons. What is the most likely diagnosis?

A 54 year old presented with speech difficulty. CT Scan showed a large compressing lesion producing a left frontal convexity. Neurosurgery performed a craniotomy with total resection of lesion. Sample of lesion was sent to Pathology, which showed cells forming bundles and whorls with intervening patternless growth. What is the most likely diagnosis?

Which of the following are antibodies that carry out damage in paraneoplastic syndromes?

Which of the following is characterized by spontaneous, arrhythmic, multidirectional saccadic eye movements along with diffuse/focal body myoclonus and truncal titubation?

Which of the following is associated with small cell lung cancer?

A child with progressive headaches, bilateral papilledema and obstructive hydrocephalus typically indicates a mass in the

Which of the following is characterized by pseudorosettes and has a bad prognosis?

What type of cells appear as fried eggs with round nuclei and clear cytoplasm?

Which of the following is characterized by filariform larvae that penetrate the skin of the feet leading to eosinophilia and GI disease?

Which of the following is characterized by multiple ring-enhancing lesions and is associated with AIDS?

Which of the following is a skin/soft tissue infection with proximal LN involvement?

Which of the following is characterized by temporal lobe edema or hemorrhage?

Which of the following can present with meningitis, cranial nerve palsies, and tabes dorsalis?

Which of the following is characterized by adult onset seizure with cystic brain lesion, as well as cigar-shaped muscle lesions?

Which of the following is characterized by psammoma bodies?

Which of the following is characterized by ring-enhancing intraparenchymal lesions with caseating granulomas?

Which of the following is an RNA virus that is transmitted to humans via mosquito that was infected by a bird and leads to acute asymmetric flaccid paralysis with lymphocytic pleocytosis in CSF?

Which of the following is associated with chromosome 17 and lisch nodules?

A Schwannoma at the cerebellopontine angle and attached to CN VIII are called

Which of the following is characterized by psychiatric disturbance, memory deficits, seizures, dyskinesias, autonomic instability, and language dysfunction?

Which of the following is characterized by Ab against Purkinje cells and is associated with small cell lung cancer, gynecologic and breast cancer, and Hodgkin lymphoma?

Which of the following is characterized by Ab against Hu antigens in neurons and is associated with small cell lung cancer?

Which of the following are a toxic gain of function mutation by alterations of protein structure?

Which of the following is a toxic gain of function mutation mediated by mRNA?

Which of the following is the only recessive repeat expansion?

SMN regulates ___ biogenesis, which is crucial to motor survival.

Normal SMN2 does not contain __, resulting in rapid degradation.

To treat SMA, Spinraza works to include ___ into the SMN2 transcript.

Which of the following is an X-linked disorder that is secondary to a mutation in the ABCD1 gene?

Which of the following is an AR lysosomal disorder affecting the white matter of the CNS and PNS, presenting in the first 6 mo of life due to a buildup of galactolipids that destroy myelin?

Which of the following is an AR arylsulfatase A gene defect resulting in the accumulation of sulfatides that accumulate to toxic levels in the nervous system and destroy myelin?

Which of the following is AD with decreased motor NCV and demyelination with onion bulb formation

A pt presents with intellectual disability, prominent forehead, large ears, long narrow face, prominent chin, and macroorchidism. What condition do they have?

What gene is mutated in Fragile X?

Fragile X is caused by

Which of the following is characterized by adult onset seizures with a cystic brain lesion from ingestion of eggs, showing round non-enhancing hypodense cysts?

Which of the following is an enveloped RNA virus in warm climates that replicates in birds and passed to mosquitoes? It presents with maculopapular rash, meningitis, encephalitis, or flaccid paralysis with lymphocytic pleocytosis on CSF?

A 24 yo M comes to a physician c/o tinnitus, hearing loss, and vertigo. On contrast T1 MRI, bilateral tumors at the cerebellopontine angle are seen so you suspect schwannoma. What condition does he have?