Question 1

When you fuse Lymphocytes and Myeloma cells in a polyethylene glycol solution what do you produce?

Accepted Answer

Hybrid-myeloma cells (poly clonal antibodies)

Answer

IgG immunoglobulins

Answer

Fab fragment

Answer

IgM immunoglobulins

Question 2

Applying Pepsin to a MoAb generates what?

Accepted Answer

https://uploads.quizalize.com/94ffb691-9f55-4c14-a0fc-ba3105ec235f/question/6714d47349c5e75a38ae4a0e13116fc61aa72dba.png

Answer

https://uploads.quizalize.com/94ffb691-9f55-4c14-a0fc-ba3105ec235f/question/5918d7ed534b1a8ddd2c43068df840de1e223bc1.png

Answer

https://uploads.quizalize.com/94ffb691-9f55-4c14-a0fc-ba3105ec235f/question/a7e75120ff0706c19b9967901af1a2a904cfdb7d.png

Answer

https://uploads.quizalize.com/94ffb691-9f55-4c14-a0fc-ba3105ec235f/question/66bcc128012fb6ab97a1e1e48eeb30d09b9d2b39.png

Question 3

Which of the following radionuclides would you want to tag an entire IgG for diagnostic imaging?

Accepted Answer

Ga-67

Answer

I-131

Answer

Y-90

Answer

Tc99m

Question 4

Identify the best fit for a therapeutic application using a whole IgG.

Accepted Answer

P-32

Answer

Tl-201

Answer

In-111

Answer

Tc99m

Question 5

A fragmented MoAb is produced in a lab.  Maxium uptake occurs within 1 hour and it completely washes out 2 hours.  Select the best radionuclide for the job.

Accepted Answer

F-18

Answer

Tc99m

Answer

I-123

Answer

I-131

Question 6

A MoAb is created for an alpha emitter.  If the avidity is weak what does this mean?

Accepted Answer

Radiolysis has a great probability of occurring

Answer

Amount of MoAb in solution is limited

Answer

Will bind to many different epitopes

Answer

MoAb has a short biological half-life

Question 7

If the Gleason some of two sames are 5 and 2.  What is the Gleason Sum?

Accepted Answer

7

Answer

2

Answer

3

Answer

5

Question 8

A patient has two PSA values one year apart.  Which of the following would be a concern that the prostate cancer has returned.

Accepted Answer

2.75 to 3.55

Answer

1.15 to 1.65

Answer

4.7 to 5.05

Answer

3.65 to 4.1

Question 9

ProstaScint has two sets up images - vascular and delay.  Which of the following results indicates prostate cancer?

Accepted Answer

Vascular cold - ProstaScint hot

Answer

Vascular hot- ProstaScint cold

Answer

Vascular cold - ProstaScint cold

Answer

Vascular hot - ProstaScint hot

Question 10

When treating a patient in palliative therapy for bone pain caused by painful bony mets, which of the following statement is NOT true?

Accepted Answer

Myelosuppression does not occur with Sr89

Answer

SM-153 and Sr89 can both cause a flare reaction

Answer

Sm-153 can be imaged with a gamma camera

Answer

Sr-89 cannot be imaged with a gamma camera

Question 11

When comparing typan blue dye to filtered sulfur colloid to lymphoseek for lymphatic mapping, which statement is true?

Accepted Answer

Sulfur colloid and lymphoseek have 100% correlation with finding the SNL

Answer

Sulfur Colloid is superior to lymphoseek when mapping the lymphatic system

Answer

Typan blue is superior to both radiopharmaceutical when mapping the lymphatic system

Answer

Lymphoseek is superior to sulfur colloid when mapping the lymphatic system

Question 12

What is the role of IV administration of amino acids when dosing Lutathera?

Accepted Answer

Reduces toxic effect to the kidneys by the radiotherapy agent

Answer

Improves the concentration of the radiotherapy agent to the tumor site

Answer

Pt has to be NPO, so this is the mechanism to give the patient nourishment

Answer

Used only as pre-treatment and discontinued after Lu-177 had be administered

Question 13

If too much MAA ends up in the lungs and Theraspheres is still administered what negative result may occur?

Accepted Answer

Radiation pneumonitis

Answer

Pulmonary Embolism

Answer

Excess radiation dosimetry to the tumor

Answer

Right to left shunt may occur

Question 14

What is the difference between the DOTAs?

Accepted Answer

Variation in binding to SST receptor cites

Answer

Concentration (mg/mL) dose

Answer

Not all of the can bind to Lu-177

Answer

NOC and TOC are more radioresistant when compared to TATE

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