Mastocytosis
Quiz by Sadeq K. Ali Al-Salait
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- Q1
What is the primary growth and differentiation factor for mast cells?
Interleukin-4 (IL-4)
Erythropoietin (EPO)
Granulocyte Colony-Stimulating Factor (G-CSF)
Tumor Necrosis Factor (TNF)
Stem Cell Factor (SCF)
30s - Q2
Which receptor on mast cells binds with high affinity to the Fc portion of IgE antibodies?
FcγR
FcμR
FcεRI
FcδR
FcαR
30s - Q3
Which granules in mast cells are rich in histamine, serotonin, and leukotrienes?
α granules
Lysosomal granules
ε granules
δ granules
β granules
30s - Q4
What marker is primarily released during the early phase of the allergic response and is a marker of mast cell activation?
Serotonin
Prostaglandin D2
Histamine
Leukotriene B4
Tryptase
30s - Q5
Which of the following is NOT a characteristic immunophenotype of normal mature mast cells?
Intermediate CD33
Positive for HLA-DR
Intermediate CD9
Low CD11b
High CD117
30s - Q6
Mastocytosis is characterized by an increase in mast cells in which of the following tissues?
All of the above
Gastrointestinal tract
Liver
Bone marrow
Skin
30s - Q7
Which mutation is identified in up to 90% of adults presenting with maculopapular cutaneous mastocytosis?
CALR del52
KIT D816V
BCR-ABL
JAK2 V617F
FLT3 ITD
30s - Q8
What clinical feature is characteristic of pediatric mast-cell disease?
Always presents with systemic symptoms
Predominantly affects the liver
Clonal myeloproliferative neoplasm
Reactive condition
Associated with JAK2 mutations
30s - Q9
What systemic symptom is commonly seen in mastocytosis due to mast-cell mediator release?
Hyperglycemia
Hypercholesterolemia
Hypernatremia
Flushing
Hypertension
30s - Q10
What is a common laboratory finding in systemic mastocytosis?
Increased hemoglobin levels
Elevated plasma glucose
Elevated alkaline phosphatase
Increased white blood cell count
Decreased serum tryptase
30s - Q11
Which immunohistochemical marker is highly specific for mast cells?
CD2
HLA-DR
Tryptase
CD25
CD30
30s - Q12
Mast cell leukemia is diagnosed based on the presence of what percentage of atypical mast cells in the marrow or blood?
≥ 20% in the marrow or ≥ 10% in the blood
≥ 25% in the marrow or ≥ 12% in the blood
. ≥ 10% in the marrow or ≥ 5% in the blood
≥ 5% in the marrow or ≥ 2% in the blood
≥ 15% in the marrow or ≥ 7% in the blood
30s - Q13
What percentage of pediatric mastocytosis cases develop the disease before the age of 15 years?
10%
15%
20%
5%
25%
30s - Q14
Which enzyme is typically elevated in the serum and is an important confirmatory finding in systemic mastocytosis?
Histamine
Leukotriene B4
Tryptase
Prostaglandin D2
Serotonin
30s