Question 1

What is the threshold platelet count to define thrombocytopenia in pregnancy?

Accepted Answer

<150 × 10⁹/L

Answer

<200 × 10⁹/L

Answer

<175 × 10⁹/L

Answer

<125 × 10⁹/L

Question 2

Which physiological factor contributes to lower platelet counts in pregnancy?

Accepted Answer

Hemodilution and increased platelet clearance

Answer

Reduced platelet production

Answer

Enhanced bone marrow suppression

Answer

Increased fibrinogen levels

Question 3

What is the most common cause of thrombocytopenia during pregnancy?

Accepted Answer

Gestational thrombocytopenia (GT)

Answer

HELLP syndrome

Answer

Acute fatty liver of pregnancy

Answer

Immune thrombocytopenic purpura (ITP)

Question 4

What percentage of thrombocytopenia cases at term are attributed to gestational thrombocytopenia (GT)?

Accepted Answer

64–80%

Answer

85–95%

Answer

30–50%

Answer

10–20%

Question 5

Which condition is characterized by thrombocytopenia with a normal coagulation profile in pregnancy?

Accepted Answer

Gestational thrombocytopenia (GT)

Answer

Acute fatty liver of pregnancy

Answer

HELLP syndrome

Answer

Disseminated intravascular coagulation (DIC)

Question 6

Which laboratory finding distinguishes immune thrombocytopenic purpura (ITP) from gestational thrombocytopenia (GT)?

Accepted Answer

Severe thrombocytopenia (<50 × 10⁹/L)

Answer

Elevated ALT/AST levels

Answer

Normal coagulation tests

Answer

Normal platelet size

Question 7

Which first-line therapy is recommended for ITP during pregnancy?

Accepted Answer

Glucocorticoids

Answer

Platelet transfusion

Answer

Rituximab

Answer

Aspirin

Question 8

What is the preferred treatment for severe thrombocytopenia in TTP during pregnancy?

Accepted Answer

Therapeutic plasma exchange

Answer

Glucocorticoids

Answer

Intravenous immunoglobulin (IVIG)

Answer

Platelet transfusion

Question 9

What distinguishes preeclampsia-related thrombocytopenia from other causes?

Accepted Answer

Proteinuria

Answer

Presence of schistocytes on peripheral smear

Answer

Platelet count <20 × 10⁹/L

Answer

Elevated creatinine with normal AST

Question 10

Which marker is commonly elevated in HELLP syndrome?

Accepted Answer

Lactate dehydrogenase (LDH)

Answer

Prothrombin time (PT)

Answer

Albumin

Answer

Platelet count

Question 11

What is the platelet count range typically seen in HELLP syndrome?

Accepted Answer

30–50 × 10⁹/L

Answer

100–150 × 10⁹/L

Answer

<30 × 10⁹/L

Answer

70–100 × 10⁹/L

Question 12

Which laboratory finding is characteristic of DIC in pregnancy?

Accepted Answer

Prolonged PT/aPTT with low fibrinogen

Answer

Decreased PT/aPTT

Answer

Elevated platelet count

Answer

Normal fibrinogen levels

Question 13

What is the underlying mechanism of TTP in pregnancy?

Accepted Answer

Severe deficiency of ADAMTS13 activity

Answer

Excessive fibrin deposition in vessels

Answer

Increased complement activation

Answer

Platelet destruction by antibodies

Question 14

What distinguishes atypical hemolytic uremic syndrome (aHUS) from TTP?

Accepted Answer

Kidney involvement with severe acute kidney injury (AKI)

Answer

Reduced complement levels

Answer

Normal ADAMTS13 levels

Answer

Neurological symptoms

Question 15

What is the mainstay of treatment for atypical HUS (aHUS) in pregnancy?

Accepted Answer

Eculizumab (anti-complement therapy)

Answer

Glucocorticoids

Answer

Rituximab

Answer

Therapeutic plasma exchange

Question 16

What differentiates acute fatty liver of pregnancy (AFLP) from HELLP syndrome?

Accepted Answer

Hypoglycemia with severe coagulopathy

Answer

Severe proteinuria

Answer

Normal bilirubin levels

Answer

Elevated platelet count

Question 17

Which lab finding supports a diagnosis of AFLP?

Accepted Answer

Severely elevated ALT&#44; AST&#44; and bilirubin levels

Answer

Elevated complement factors

Answer

Normal ALT and AST levels

Answer

Normal LDH levels

Question 18

Which treatment is crucial for AFLP management?

Accepted Answer

Immediate delivery of the fetus

Answer

Eculizumab

Answer

Plasma exchange therapy

Answer

High-dose glucocorticoids

Question 19

What is the diagnostic test for shiga toxin-mediated HUS?

Accepted Answer

Stool culture for shiga toxin-producing bacteria

Answer

Serological test for Shigella bacterium

Answer

Peripheral smear for schistocytes

Answer

ADAMTS13 activity measurement

Question 20

Which clinical condition has the highest risk of maternal and fetal mortality in pregnancy-related thrombocytopenia?

Accepted Answer

Acute fatty liver of pregnancy (AFLP)

Answer

HELLP syndrome

Answer

Immune thrombocytopenic purpura

Answer

Gestational thrombocytopenia

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